| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Glycogen phosphorylase (GP) is a typical allosteric enzyme with several different ligand-binding sites, thus offering multiple opportunities for inhibition of the catalytic activity. Characterization of the properties of these sites indicated that the GP storage site does not directly affect the action of the GP catalytic site. In the GP catalytic site, there are two subsites, which might play important roles in the catalytic action of GP. However, I could not find a selective inhibitor of liver-type GP.
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