Ultra-sonic songs in mice:functional analysis of vocal control mechanisms

• Project/Area Number: 23653220
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Experimental psychology
• Research Institution: The University of Tokyo
• Principal Investigator: OKANOYA Kazuo 東京大学, 大学院・総合文化研究科, 教授 (30211121)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: マウス / 求愛歌 / 聴覚 / 発声 / 性行動 / 扁桃体 / 遺伝子改変マウス / 超音波発声 / 国際研究者交流 / 米国 / 台湾 / 遺伝子改変 / 動機づけ / 学習

Research Abstract

We studied the mechanisms of vocal production in ultra-sonic songs in male mice in relation to auditory feedback and motivation. We measured the relationship between vocal production and auditory sensitivity in normal and genetically modified mice. We also lesioned amygdala to see the effects in song production. In cadherin-6 knockout mice, the pitch increased in mating songs but there were no changes in auditory sensitivity. In amygdale lesioned mice complex elements were disappeared.

Research Products

• [Journal Article] Effects of amygdala lesions on male mouse ultrasonic vocalizations and copulatory behaviour (2012)
  • Author(s): Matsumoto, YK., Okanoya, K., & Seki, Y.
  • Journal Title: Neuroreport Volume: 23 Issue: 11 Pages: 676
  • DOI: 10.1097/wnr.0b013e3283557eea
  • URL: https://pure.teikyo.jp/en/publications/f198a980-e69f-4961-80fe-d70c5c4fa6ee
  • Peer Reviewed
• [Journal Article] Defects in Ultrasonic Vocalization of Cadherin-6 Knockout Mice (2012)
  • Author(s): Nakagawa, R., Matsunaga, E., & Okanoya K
  • Journal Title: PLoS One Volume: 7 Issue: 11 Pages: e49233-e49233
  • DOI: 10.1371/journal.pone.0049233
  • URL: https://pure.teikyo.jp/en/publications/63633bce-29ce-42a4-a34a-cb6fab3d8a8f
• [Presentation] C57BL/6マウスの求愛歌に及ぼす扁桃体損傷の効果 (2012)
  • Author(s): 松本結、関義正、岡ノ谷一夫
  • Organizer: 日本動物心理学会第72回大会
  • Place of Presentation: 西宮市、兵庫.
• [Presentation] オペラント学習の進度指標としてのラット超音波発声 (2012)
  • Author(s): 結城笙子、松本結、関義正、岡ノ谷一夫
  • Organizer: 日本動物心理学会第72回大会
  • Place of Presentation: 西宮市、兵庫.
• [Presentation] Amygdala lesion affects ultrasonic courtship vocalization in male mice (2012)
  • Author(s): Yui Matsumoto, Kazuo Okanoya, Yoshimasa Seki
  • Organizer: Workshop on Mouse Ultrasonic Communication.
  • Place of Presentation: Paris, France
• [Presentation] Amygdala lesion affects ultrasonic courtship vocalizations (2012)
  • Author(s): Matsumto, Y. & Okanoya, K.
  • Organizer: Workshop on mouse ultrasonic communication
  • Place of Presentation: パスツール研究所（フランス、パリ）
• [Presentation] C57BL/6マウスの求愛歌に及ぼす扁桃体損傷の効果 (2012)
  • Author(s): 松本結、関義正、岡ノ谷一夫
  • Organizer: 日本動物心理学会第72回大会
  • Place of Presentation: 関西学院大学上ケ原キャンパス（兵庫県、西宮市）
• [Presentation] オペラント学習の進度指標としてのラット超音波発声 (2012)
  • Author(s): 結城笙子、松本結、関義正、岡ノ谷一夫
  • Organizer: 日本動物心理学会第72回大会
  • Place of Presentation: 関西学院大学上ケ原キャンパス（兵庫県、西宮市）
• [Presentation] マウスの発声行動におけるカドヘリン6の役割 (2011)
  • Author(s): 仲川涼子, 松永英治, 岡ノ谷一夫
  • Organizer: Animal2011
  • Place of Presentation: 東京
• [Presentation] マウスの発声行動におけるカドヘリン６の役割 (2011)
  • Author(s): 仲川涼子、松永英治、岡ノ谷一夫
  • Organizer: 日本動物心理学会第７１回大会（Animal 2011）
  • Place of Presentation: 慶応義塾大学