| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
A cationic gold(I) complex bearing a semihollow-shaped triethynylphosphine ligand efficiently catalyzed cyclizations of various alkynes tethered to different nucleophilic functional groups such as alcohols, sulfonamides, and silyl enol ethers due to an entropy-based rate enhancement. Trityl-based semihollow triethynylphosphines were synthesized and employed as ligands in the gold-catalyzed 8-exo-dig cyclization of acetylene-tethered silyl enol ethers to obtain eight-membered-ring carbocycles.
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