Development of atom-economical multicomponent coupling reactions via hypervalent ate complexes
| Project/Area Number |
23655043
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
YOSHIDA Hiroto 広島大学, 大学院・工学研究院, 准教授 (40335708)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アライン / 多成分連結反応 / 超原子価アート錯体 |
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| Research Abstract |
We have developed multicomponent coupling reactions, where zwitterions derived from arynes and neutral nucleophiles are trapped by alkynyl or perfluoroaryl bromides. These reactions proceed through formation of hypervalent ate complexes generated from aryl anion moieties of the zwitterions and bromine moieties of the organic bromides. Isocyanides and cyclic ethers (THF, oxetane) can serve as neutral nucleophiles in the reaction. Furthermore, total synthesis of a biologically active molecule has been achieved by using the oxetane-derived product.
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Report
(3 results)
Research Products
(4 results)
