| Project/Area Number |
23655050
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Inorganic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
ONODA Akira 大阪大学, 大学院・工学研究科, 助教 (60366424)
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| Co-Investigator(Renkei-kenkyūsha) |
TAHASHI Takashi 大阪大学, 大学院・工学研究科, 教授 (20222226)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 生物無機化学 / タンパク質 / 人工金属タンパク質 / 二核中心 / 人工金属酵素 / 鉄二核酵素 / ヘムエリスリン / メタンモノオキゲナーゼ / 酸素センサータンパク質 / 酸化反応 / 金属タンパク質 / 多核金属錯体 / 鉄二核中心 / 人工タンパク質 |
|---|
| Research Abstract |
Metalloenzymes catalyze variety of reactions including hydroxylation of methane and nitrogen fixation, which are difficult for synthetic catalysts, in mild conditions. Thus, the active site of these metalloenzyme has been attracted the chemists. In this project, the artificial biocatalysts containing non-natural dimetallic active sites were constructed.The first coordination shell of the active site was reengineered and the second coordination shell was redesigned. The structure and function of the resultant artificial biocatalysts were studied.
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