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Design of Dual Imaging Probes for Magnetic Resonance and Luminescence via Self-assembly of Lanthanide and Thiacalixarene

Research Project

Project/Area Number 23655060
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Analytical chemistry
Research InstitutionTohoku University

Principal Investigator

IKI Nobuhiko  東北大学, 大学院・環境科学研究科, 准教授 (50282108)

Co-Investigator(Kenkyū-buntansha) HOSHINO Hitoshi  東北大学, 大学院・環境科学研究科, 教授 (20124620)
TAKAHASHI Toru  福井大学, 大学院・工学研究科, 講師 (30361166)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsイメージングプローブ / 発光イメージング / 磁気共鳴イメージング / ランタニド / チアカリックスアレーン
Research Abstract

The study is aimed at a developing dual imaging probe (DIP) for magnetic resonance imaging (MRI) and luminescence imaging to enhance the sensitivity and resolution of the current imaging techniques. Here we used thiacalixarene as a clustering ligand for multi-lanthanide core enabling both magnetic relaxation and luminescence. We have successfully elucidated that the multi-nuclear complex fulfill prerequisites for DIP such as (1) formation of single species, (2) high kinetic stability, (3) relaxivity, and(4) luminescence functions.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (23 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (13 results) Book (2 results) Remarks (2 results)

  • [Journal Article] The role of cadmium(II) bridges in the self-assembly with lanthanide(III) and thiacalix[4]arene (TCAS) to selectively form a luminescent ternary CdII2·TbIII2·TCAS2 complex2012

    • Author(s)
      Nobuhiko Iki
    • Journal Title

      Inorg. Chim. Acta

      Volume: 397 Pages: 42-47

    • DOI

      10.1016/j.ica.2012.11.016

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kinetically Stable LnIII Complexes Comprising a Trinuclear Core Sandwiched between Two Thiacalix[4]arene Ligands Self-Assembled in Water (LnIII = NdIII, YbIII)2012

    • Author(s)
      Nobuhiko Iki
    • Journal Title

      Eur. J. Inorg. Chem.

      Volume: 2012 Issue: 22 Pages: 3541-3545

    • DOI

      10.1002/ejic.201200464

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Near Infrared Fluorescence Labeling Reagent : Synthesis of Indole-Functionalized Indocyanine Green Derivatives2012

    • Author(s)
      T. Doi, K. Oikawa, J. Suzuki, M. Yoshida, N. Iki
    • Journal Title

      Synlett

      Volume: 2 Issue: 02 Pages: 306-310

    • DOI

      10.1055/s-0031-1290139

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Highly Efficient Near-Infrared-Emitting Lanthanide(III) Complexes Formed by Heterogeneous Self-Assembly of Ag, Ln, and Thiacalix[4]arene-p-tetrasulfonate in Aqueous Solution (Ln=Nd, Yb)2012

    • Author(s)
      Nobuhiko Iki, Shouichi Hiro-oka, Teppei Tanaka, Chizuko Kabuto, Hitoshi Hoshino
    • Journal Title

      Inorganic Chemistry

      Volume: 51 Issue: 3 Pages: 1648-1656

    • DOI

      10.1021/ic2019583

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Highly Efficient Near-Infrared-Emitting Lanthanide(III) Complexes Formed by Heterogeneous Self-Assembly of AgI, LnIII, and Thiacalix[4]arene-p-tetrasulfonate in Aqueous Solution (LnIII = NdIII, YbIII)2012

    • Author(s)
      Nobuhiko Iki, Shouichi Hiro-oka, Teppei Tanaka, Chizuko Kabuto, and Hitoshi Hoshino
    • Journal Title

      Inorg. Chem.

      Volume: 51 Pages: 1648-1656

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] pH-Responsive Switching of Near-Infrared Absorption of a Diradical Complex of Pt^<II> and 3,4-Diamino- benzoate Formed in Aqueous Solutions2011

    • Author(s)
      Kousaku Tamura, Atsuko Masuya, Nobuhiko Iki, Yasunori Ohba, Seigo Yamauchi, and Hitoshi Hoshino
    • Journal Title

      Inorg. Chim. Acta

      Volume: 378 Issue: 1 Pages: 81-86

    • DOI

      10.1016/j.ica.2011.08.018

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ガドリニウム-チアカリックスアレーン多核錯体の速度論的安定性と1H磁気緩和能の評価2013

    • Author(s)
      中村真実,壹岐伸彦,Eszter Boros,Peter Caravan
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学
    • Year and Date
      2013-03-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 水溶液中におけるチアカリックスアレーン-ランタニド(III)多核錯体の自己組織化と速度論的安定性2012

    • Author(s)
      壹岐伸彦,中村真実,星野仁
    • Organizer
      錯体化学会第62回討論会
    • Place of Presentation
      富山大学
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 高安定性を有するランタニド-チアカリックスアレーン錯体の自己組織化と速度論的安定性の評価2012

    • Author(s)
      中村真実,壹岐伸彦,星野仁
    • Organizer
      日本分析化学会第61年会
    • Place of Presentation
      金沢大学
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 水溶液を反応場とする多元金属複核錯体の自己組織化挙動を解き明かす2012

    • Author(s)
      壹岐伸彦,田中鉄兵,中村真実,廣岡祥一,星野仁
    • Organizer
      第72回分析化学討論会
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2012-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Self-assembly of Thiacalix[4]arene and Ln^<III> to Kinetically Stable Complexes2012

    • Author(s)
      Nobuhiko Iki, Shouichi Hiro-oka, Mami Nakamura, Teppei Tanaka, Hitoshi Hoshino
    • Organizer
      40 International Conference onCoordination Chemistry
    • Place of Presentation
      Valencia, Spain
    • Related Report
      2012 Final Research Report
  • [Presentation] Self-assembly of Thiacalix[4]arene and LnIII to Kinetically Stable Complexes2012

    • Author(s)
      Nobuhiko Iki
    • Organizer
      40 International Conference on Coordination Chemistry
    • Place of Presentation
      Valencia, Spain
    • Related Report
      2012 Annual Research Report
  • [Presentation] チアカリックスアレーンの精密認識能による超分子ランタニド錯体の自律的形成2011

    • Author(s)
      壹岐伸彦・広岡祥一・田中鉄兵・星野仁
    • Organizer
      第7回ホスト・ゲスト化学シンポジウム
    • Place of Presentation
      広島大学
    • Related Report
      2011 Research-status Report
  • [Presentation] チアカリックスアレーンの金属イオン精密認識能を基盤とする発光性ランタニド錯体の自律形成2011

    • Author(s)
      田中鉄兵・広岡祥一・壹岐伸彦・星野 仁
    • Organizer
      化学系学協会東北大会
    • Place of Presentation
      東北大学
    • Related Report
      2011 Research-status Report
  • [Presentation] チアカリックスアレーンの精密認識能による超分子ランタニド錯体の自律的形成2011

    • Author(s)
      壹岐 伸彦・広岡 祥一・田中 鉄兵・星野 仁
    • Organizer
      日本分析化学会第60年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 水溶液を反応場とする多元金属複核錯体の自己組織化挙動を解き明かす

    • Author(s)
      壹岐伸彦
    • Organizer
      第72回分析化学討論会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高安定性を有するランタニド-チアカリックスアレーン錯体の自己組織化と速度論的安定性の評価

    • Author(s)
      中村真実
    • Organizer
      日本分析化学会第61年会
    • Place of Presentation
      金沢大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 水溶液中におけるチアカリックスアレーン-ランタニド(III)多核錯体の自己組織化と速度論的安定性

    • Author(s)
      壹岐伸彦
    • Organizer
      錯体化学会第62回討論会
    • Place of Presentation
      富山大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] ガドリニウム-チアカリックスアレーン多核錯体の速度論的安定性と1H磁気緩和能の評価

    • Author(s)
      中村真実
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学
    • Related Report
      2012 Annual Research Report
  • [Book] Capillary Electrophoresis and Microchip Capillary Electrophoresis: Principles, Applications, and Limitations2013

    • Author(s)
      Toru Takahashi, Nobuhiko Iki
    • Publisher
      Wiley
    • Related Report
      2012 Final Research Report
  • [Book] Capillary Electrophoresis and Microchip Capillary Electrophoresis: Principles, Applications, and Limitations2013

    • Author(s)
      Toru Takahashi
    • Publisher
      Wiley
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      https://sites.google.com/site/hoshlab/

    • Related Report
      2012 Final Research Report
  • [Remarks] チアカリックスアレーンの多機能性創発 - 超分子金属錯体の創製と分析化学的応用

    • URL

      https://sites.google.com/site/hoshlab/research/tca

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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