Development of chiral nano-space using highly-ordered molecular gel for molecular recognition
Project/Area Number |
23655069
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Analytical chemistry
|
Research Institution | Kumamoto University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
GANAPATHY S Hullacy 熊本大学, 大学院・先導機構, 助教 (90551276)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | キラル超分子集合体 / 分子認識 / 液体クロマトグラフィー / 異性体分離 / キラル超分子 |
Research Abstract |
Glutamide-derivatives with a triethoxysilyl group (CmGDD) was newly synthesized and confirmed to form fibrous self-assembly in various organic solvents. CmGDD was grafted onto the surface of porous silica particles through siloxane bonds (Sil-CmGDD) for use in reversed-phase HPLC as a stationary phase. Solid-state 13C NMR and DSC measurements indicate that CmGDD can form highly-oriented structures on the silica surface. The Sil-C10GDD packed-column was investigated by retention studies of polycyclic aromatic hydrocarbons. The chromatographic results showed that the Sil-CmGDD provided excellent selectivity for these isomers such as stilbenes and terphenyls than conventional octadecylated silica. It is estimated that these preferable results can be brought about through hydrogen bond-mediated molecular orientation of weak interaction sites such as carbonyl groups. Sil-CmGDD also showed excellent separations of bio-related molecules such as tocopherols isomers and Vitamine Ds.
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Report
(4 results)
Research Products
(24 results)