| Project/Area Number |
23655072
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Analytical chemistry
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
TOKONAMI Shiho 大阪府立大学, 21世紀科学研究機構, 講師 (60535491)
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| Co-Investigator(Kenkyū-buntansha) |
IIDA Takuya 大阪府立大学, 21 世紀科学研究機構, 講師 (10405350)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | バイオセンサ / 光検出 / ラベルフリー / 金属ナノ粒子 / 生体分析 / ナノ構造体 / 光機能 |
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| Research Abstract |
In this study, we performed the chemical design of the arrangement of metallic nanoparticles and the shape of nanostructures for aiming at the development of highly sensitive optically-driven biosensor, the local temperature sensor and so on. As a fundamental achievement, it has been clarified that linear and nonlinear optical responses can be significantly enhanced by fixing metallic (Au or Ag) nanoparticles densely onto a plastic bead with binder molecules. Also, in the similar system, we have revealed that the optical control of heat coagulation, and we have obtained an important knowledge for the development of temperature sensor based on the optical detection in nano- and micro-spaces. Furthermore, we have clarified that light scattering decreases or increases at particular wavelength regions by binding heterogeneous metallic nanostructures via DNA. This result indicates the possibility that a small amount of DNA less than amol can be detected even by white light irradiation.
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