| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
An efficient catalyst system was established for Suzuki-Miyaura coupling of branched alkylboron reagents bearing a nitrogen functional group at the a-position. Stereochemical course of the reaction was switchable by additives. The carbon-carbon bond formation took place with inversion of configuration, when the reaction was carried out with phenol. In contrast, zirconium alkoxide mediated the reaction with retention of configuration. Two enantiomers of optically active nitrogen-containing organic compounds could be synthesized effectively by this method.
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