| Project/Area Number |
23655089
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Keio University |
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Principal Investigator |
YAMADA Toru 慶應義塾大学, 理工学部, 教授 (40296752)
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| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | 合成化学 / 触媒・化学プロセス / マイクロ波 / 選択的合成 / 不斉合成 |
|---|
| Research Abstract |
We here report the effect of microwave irradiation on the atropo-enantioselective ring-opening reaction of biaryl lactones with dynamickinetic resolution catalyzed by AgBF_4phosphine complexes. The multimode microwave reactor with a cooling system was employed and the fiber-optic sensor was used for measurement of the accurate internal reaction temperature. It was found that the reaction was accelerated by microwave irradiation without any loss of enantioselectivity at almost the same internal temperature as the conventional conditions. On the basis of Arrhenius plots on the present reaction, it was confirmed that the microwave effect was not only their simple heating effect.
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