Development of innovative embolization materials using host molecules modified polymers
| Project/Area Number |
23655104
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Polymer chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
HARADA Akira 大阪大学, 理学研究科, 教授 (80127282)
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| Co-Investigator(Kenkyū-buntansha) |
OSUGA Keigo 大阪大学, 医学研究科, 講師 (90332741)
HIDAKA Kuniyuki 大阪大学, 医学部附属病院, 診療放射線技師 (50437430)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 生体関連高分子 / 血管内塞栓物質 / ゲスト相互作用 / ヒドロゲル / シクロデキストリン / 自己修復性 / 刺激応答性 / ホスト－ゲスト相互作用 |
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| Research Abstract |
In the modern world, expanding the useful lifespan of materials is becoming highly desirable. Thus, self-healing and self-repairing materials should become valuable commodities. To create self-healing materials, our research focuses on the formation of supramolecular materials through host-guest interactions, which is a powerful method to create nonconventional materials. We employ CD and aliphatic groups as host and guest molecules, respectively, to construct supramolecular self-healing materials. Host-guest interactions have unique features due to selective complementary interactions, which have easily tuned material strength and self-healing efficiencies. Supramolecular materials formed by host-guest interactions recover to the initial strength even after the materials were cut in half, and then rejoined. Moreover, we report the formation of supramolecular hydrogels and their redox-responsiveand self-healing properties due to host-guest interactions, Redox stimuli induce a solgel phase transition in the supramolecular hydrogel and can control self-healing properties such as re-adhesion between cut surfaces.
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Report
(3 results)
Research Products
(54 results)
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[Presentation] 超分子相互作用が”見える”高分子材料2012
Author(s)
Akira Harada
Organizer
The 16th International Cyclodextrin Symposium (ICS16)
Place of Presentation
Nankai University, Tianjin, China
Related Report
Invited
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