Synthesis of amphiphilic polymers exhibiting liquid crystallinity at room temperature and their self-assembling in water
Project/Area Number |
23655107
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Polymer chemistry
|
Research Institution | Kansai University |
Principal Investigator |
MIYATA Takashi 関西大学, 化学生命工学部, 教授 (50239414)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 液晶高分子 / 両親媒性高分子 / 自己集合 / 高分子ミセル / メソゲン基 / 臨界ミセル濃度 / DDS / 相転移 / 液晶性高分子 / DDS |
Research Abstract |
Novel amphiphilic liquid crystalline polymers (LCP-g-PEGs) exhibiting phase transition at body temperature were synthesized by introducing both hydrophobic mesogenic groups and hydrophilic PEG chains onto a polysiloxane main chain using hydrosilylation reaction. Self-assembly of LCP-g-PEG in an aqueous solution resulted in the micelle formation by hydrophobic interaction. Hydrophobic model drugs such as pyrene and fluorescein were loaded into the LCP-g-PEG micelles and their temperature-responsive drug release was investigated. The drug release from LCP-g-PEG micelles was enhanced above the phase transition temperature of LCP-g-PEG. The LCP-g-PEG micelles have potential applications as smart drug carriers for drug delivery systems.
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Report
(3 results)
Research Products
(40 results)