Research Project
Grant-in-Aid for Challenging Exploratory Research
Novel amphiphilic liquid crystalline polymers (LCP-g-PEGs) exhibiting phase transition at body temperature were synthesized by introducing both hydrophobic mesogenic groups and hydrophilic PEG chains onto a polysiloxane main chain using hydrosilylation reaction. Self-assembly of LCP-g-PEG in an aqueous solution resulted in the micelle formation by hydrophobic interaction. Hydrophobic model drugs such as pyrene and fluorescein were loaded into the LCP-g-PEG micelles and their temperature-responsive drug release was investigated. The drug release from LCP-g-PEG micelles was enhanced above the phase transition temperature of LCP-g-PEG. The LCP-g-PEG micelles have potential applications as smart drug carriers for drug delivery systems.
All 2012 2011 Other
All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (32 results) (of which Invited: 3 results) Book (2 results) Patent(Industrial Property Rights) (1 results)
Polym. J.
Volume: 44 Pages: 625-631
Colloids Surf. B: Biointerfaces
Volume: 99 Pages: 74-81
機能材料
Volume: 32 Pages: 50-56
10024164597
高分子
Volume: 60 Pages: 821-825
10029795717
科学と工業
Volume: 85 Pages: 249-257
