Development of supramolecular systems for the regulation of bio-supramolecular functions
| Project/Area Number |
23655136
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional materials chemistry
|
|---|
| Research Institution | Kobe Gakuin University |
|---|
Principal Investigator |
YUAN De-Qi 神戸学院大学, 薬学部, 教授 (70304962)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 超分子化学 / 人工レセプター / 分子認識 / cucurbit[n]uril / シクロデキストリン |
|---|
| Research Abstract |
An convenient method has been established for the synthesis and purification of cucurbit[7]uril. The binding behavior of cucurbit[7]uril and a large variety of guest compounds including acetylcholine and their analogs has been investigated. Cucurbit[7]uril binds acetylcholine with very strong affinity that competing natural acetylcholine receptors. It was clarified that cucurbit[7]uril binds the onium ions deep in its cavity to form very stable inclusion complexes. Cucurbit[7]uril also forms stable inclusion complexes with neutral guests of the similar shape and size to that of onium ions but confronts much higher energy barriers.
|
Report
(4 results)
Research Products
(12 results)
