Development of supramolecular systems for the regulation of bio-supramolecular functions

• Project/Area Number: 23655136
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Functional materials chemistry
• Research Institution: Kobe Gakuin University
• Principal Investigator: YUAN De-Qi 神戸学院大学, 薬学部, 教授 (70304962)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 超分子化学 / 人工レセプター / 分子認識 / cucurbit[n]uril / シクロデキストリン

Research Abstract

An convenient method has been established for the synthesis and purification of cucurbit[7]uril. The binding behavior of cucurbit[7]uril and a large variety of guest compounds including acetylcholine and their analogs has been investigated. Cucurbit[7]uril binds acetylcholine with very strong affinity that competing natural acetylcholine receptors. It was clarified that cucurbit[7]uril binds the onium ions deep in its cavity to form very stable inclusion complexes. Cucurbit[7]uril also forms stable inclusion complexes with neutral guests of the similar shape and size to that of onium ions but confronts much higher energy barriers.

Research Products

• [Journal Article] Synthesis and Binding Behaviors of Monomethyl Cucurbit[6]uril (2011)
  • Author(s): M. A. Mostafa, K. Koga, M. Fukudome, H. Sasaki, D.-Q. Yuan
  • Journal Title: Tetrahedron Lett Volume: 52 Pages: 646-4649
• [Journal Article] Synthesis and binding behaviors of monomethyl cucurbit[6]uril (2011)
  • Author(s): M. M. Ahmed, K. Koga, M. Fukudome, H. Sasaki, D.-Q. Yuan
  • Journal Title: Tetrahedron Letters Volume: 52 Issue: 36 Pages: 4646-4649
  • DOI: 10.1016/j.tetlet.2011.06.110
  • Peer Reviewed
• [Presentation] アシルホモセリンラクトンをターゲットとする人工レセプターの合成を目指したcucurbit[6]urilの水溶化 (2013)
  • Author(s): 瀧本竜哉, 山内章嗣, 杉田康, 橘亮介, 袁徳其, 佐々木秀明
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] 藤田佳平衛重塩酸中におけるシクロデキストリン誘導体閉環反応のNMR 解析 (2013)
  • Author(s): 福留誠, 内藤潤, 袁徳其
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] AHL 人工レセプターの創製を目指したシクロデキストリン誘導体の合成と分子認識 (2013)
  • Author(s): 田中詩織, 堺陽子, 古賀和隆, 福留誠, 袁徳其
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] 重塩酸中におけるシクロデキストリン誘導体閉環反応のNMR解析 (2013)
  • Author(s): 福留 誠、内藤 潤、袁 徳其、藤田佳平衛
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] AHL人工レセプターの創製を目指したシクロデキストリン誘導体の合成と分子認識 (2013)
  • Author(s): 田中 詩織、堺 陽子、古賀 和隆、福留 誠、袁 徳其
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] Syntheses of Cyclomannins from Cyclodextrins (2012)
  • Author(s): D.-Q. Yuan, K. Koga, M. Fukudome
  • Organizer: The 16th International Cyclodextrin Symposium
  • Place of Presentation: Tianjin, China
  • Invited
• [Presentation] Site-specific Cleavage of Modified Cyclodextrins to Linear Oligosaccarides (2012)
  • Author(s): M. Fukudome, K. Fujita, D.-Q. Yuan
  • Organizer: The 16th International Cyclodextrin Symposium
  • Place of Presentation: Tianjin, China
  • Invited
• [Presentation] シクロデキストリン二級水酸基側ヘテロ二官能化を経由する修飾マルトヘプタオースの合成と構造 (2012)
  • Author(s): 福留誠, 内藤潤, 藤田佳平衛, 袁徳其
  • Organizer: 第29回シクロデキストリンシンポジウム
  • Place of Presentation: 東京
• [Presentation] AHL 類クオルモン人工レセプターの合成と分子認識機能 (2011)
  • Author(s): 堺洋子, 小塩和人, 楊成, 福留誠, 袁徳其
  • Organizer: 第61回日本薬学会近畿支部大会
  • Place of Presentation: 神戸
• [Presentation] AHL類クオルモン人工レセプターの合成と分子認識機能 (2011)
  • Author(s): 堺洋子、小塩和人、楊成、福留誠、袁徳其
  • Organizer: 第61回日本薬学会近畿支部大会
  • Place of Presentation: 神戸