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Development of Biocompatible Co-continuous Membrane for Immune Depression

Research Project

Project/Area Number 23655149
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Chemistry related to living body
Research InstitutionKyoto Prefectural University

Principal Investigator

HOSOYA Ken  京都府立大学, 大学院・生命環境科学研究科, 教授 (00209248)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords免疫 / 生体適合性 / 共連続体 / 移植 / 膵島 / 共重合体 / 糖尿病 / インシュリン / QOL
Research Abstract

Biocompatible, co-continuous membranes which excluded immune cells but crossed by oxygen, glucose, and insulin were developed. A co-continuous membrane derived from poly-ethylene glycol based monomer showed excellent biocompatibility and controlled adhesion of tissue, while good vascularization was observed in rat body. Asmall bag for subcutaneous implant was also experimentally produced.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (31 results)

All 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (13 results) (of which Invited: 1 results) Remarks (7 results)

  • [Journal Article] Simple LC using New Macroporous Polymers.2013

    • Author(s)
      K. Hosoya
    • Journal Title

      Chromatography

      Volume: 34 Pages: 1-22

    • NAID

      10031159493

    • URL

      http://chromsoc.jp/Journal/pdf/34-1_1.pdf

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antibacterial Activities Effectuated by Co-continuous Epoxy-based Polymer Materials2013

    • Author(s)
      T. Kubo, K. Yasuda, Y. Tominaga, K. Otsuka, K. Hosoya
    • Journal Title

      Colloids and Surfaces B

      Volume: 107 Pages: 53-58

    • DOI

      10.1016/j.colsurfb.2013.01.043

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple LC using New Macroporous Polymers2013

    • Author(s)
      K. Hosoya
    • Journal Title

      Chromatography,

      Volume: 34 Pages: 1-22

    • NAID

      10031159493

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific chromatographic retentions on polymer pore-surface of macroporous spongy monoliths2012

    • Author(s)
      T. Tanigawa, T. Kubo, and K. Hosoya
    • Journal Title

      Chem. Lett

      Volume: 41 Pages: 1265-1266

    • NAID

      10031120653

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive study of proteins that interact with microcystin-LR2012

    • Author(s)
      T. Mori, T. Kubo, K. Kaya, and K. Hosoya
    • Journal Title

      Anal. Bioanal. Chem

      Volume: 402 Pages: 1137-1147

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive study of proteins that interact with microcystin-LR2012

    • Author(s)
      T. Mori, T. Kubo, K. Kaya, and K. Hosoya,
    • Journal Title

      Anal. Bioanal. Chem.

      Volume: 402 Issue: 3 Pages: 1137-1147

    • DOI

      10.1007/s00216-011-5514-1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of molecularly imprinted porous polymers for selective adsorption of gaseous compounds2012

    • Author(s)
      Y.Tominaga, T.Kubo, K.Yasuda, K.Kato, K.Hosoya
    • Journal Title

      Microporous and Mesoporous Materials

      Volume: 156 Pages: 161-165

    • DOI

      10.1016/j.micromeso.2012.02.020

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Specific chromatographic retentions on polymer pore-surface of macroporous spongy monoliths2012

    • Author(s)
      T.Tanigawa, T. Kubo, and K. Hosoya
    • Journal Title

      Chem. Lett.

      Volume: Vol.41, No.10 Issue: 10 Pages: 1265-1266

    • DOI

      10.1246/cl.2012.1265

    • NAID

      10031120653

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymers of 2-methacryloyloxyethyl phosphorylcholine truly work as cell membrane mimic ?2012

    • Author(s)
      T. Mori, T. Kubo, and K. Hosoya
    • Journal Title

      Colloid Surface B

      Volume: 84 Pages: 181-186

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comprehensive research of proteins interacting with Microcystin-LR2012

    • Author(s)
      T. Mori, T. Kubo, K. Kaya, and K. Hosoya,
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 402 Pages: 1137-1147

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polymers of 2-methacryloyloxyethyl phosphorylcholine truly work as cell membrane mimic ?2011

    • Author(s)
      T. Mori, T. Kubo, and K. Hosoya
    • Journal Title

      Colloids Surf. B,

      Volume: 84 Issue: 1 Pages: 181-186

    • DOI

      10.1016/j.colsurfb.2010.12.033

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Development of novel hydrogels responsive for molecular recognition2013

    • Author(s)
      Y. Tominaga, T. Kubo, K. Otsuka, K. Hosoya,
    • Organizer
      PITTCON2013
    • Place of Presentation
      Philadelphia (USA),
    • Related Report
      2012 Annual Research Report
  • [Presentation] 親水性ハイブリッドポリマーの調製と評価2012

    • Author(s)
      伊藤晴香, 谷川哲也,久保拓也, 細矢 憲
    • Organizer
      第23回クロマトグラフィー科学会議
    • Place of Presentation
      岐阜
    • Year and Date
      2012-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] PEG 系ヒドロゲルの分子認識刺激に基づく膨潤・収縮挙動の基礎評価2012

    • Author(s)
      冨永雄一,久保拓也,末吉健志, 細矢 憲,大塚浩二
    • Organizer
      第23回クロマトグラフィー科学会議
    • Place of Presentation
      岐阜
    • Year and Date
      2012-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] スポンジモノリスの保持特性及び機能化の検討2012

    • Author(s)
      谷川哲也, 久保拓也, 細矢 憲
    • Organizer
      第23回クロマトグラフィー科学会議
    • Place of Presentation
      岐阜
    • Year and Date
      2012-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 機能性高分子多孔体の開発とクロマトグラフィー分析の簡便化2012

    • Author(s)
      細矢 憲
    • Organizer
      第23回クロマトグラフィー科学会議
    • Place of Presentation
      岐阜
    • Year and Date
      2012-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 分子刺激応答性ヒドロゲルを用いた水溶性化合物の選択的捕捉2012

    • Author(s)
      冨永雄一,久保拓也,細矢 憲,大塚浩二
    • Organizer
      日本分析化学会第61 年会
    • Place of Presentation
      金沢
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 多層型親水性ハイブリッドポリマー充てん剤の調製とその基本特性2012

    • Author(s)
      伊藤晴香,久保拓也,細矢 憲
    • Organizer
      第19回クロマトグラフィーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-05-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Mystery of molecular recognition ability on surface of polymer-based macroporous media2012

    • Author(s)
      T. Tanigawa, T. Kubo, K. Hosoya
    • Organizer
      IACIS2012, Sendai (Japan)
    • Place of Presentation
      Poster
    • Year and Date
      2012-05-23
    • Related Report
      2012 Final Research Report
  • [Presentation] ポリエチレン-ポリ酢酸ビニル混合物( EVA )スポンジモノリスカラムの保持特性評価2012

    • Author(s)
      谷川哲也, 加藤啓太, 久保拓也, 渡部悦幸, 細矢憲
    • Organizer
      第19回クロマトグラフィーシンポジウム
    • Place of Presentation
      八王子市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 分子刺激応答性ヒドロゲルを用いた水溶性化合物の選択的捕捉2012

    • Author(s)
      冨永雄一,久保拓也,細矢憲,大塚浩二
    • Organizer
      日本分析化学会第61年会
    • Place of Presentation
      金沢市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 分子認識刺激応答・伸縮性ヒドロゲルの開発2012

    • Author(s)
      久保拓也,冨永雄一,細矢憲,大塚浩二
    • Organizer
      第21回ポリマー材料フォーラム
    • Place of Presentation
      北九州市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 機能性高分子多孔体の開発とクロマトグラフィー分析の簡便化2012

    • Author(s)
      細矢 憲
    • Organizer
      第23回クロマトグラフィー科学会議
    • Place of Presentation
      岐阜市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 有機ポリマー基材LC固定相の不思議 -分子認識の一側面-2012

    • Author(s)
      細矢 憲
    • Organizer
      第15回 近畿分析技術研究懇談会講演会(招待講演)
    • Place of Presentation
      大阪科学技術センター
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.kpu.ac.jp/cmsfiles/contents/0000001/1645/13.pdf

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://chromsoc.jp/Secretariat/pdf2/profile2012.pdf

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www2.kpu.ac.jp/life_environ/poly_mat_design/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 細矢憲の学会賞情報

    • URL

      http://chromsoc.jp/Secretariat/pdf2/profile2012.pdf

    • Related Report
      2012 Annual Research Report
  • [Remarks] 大学シーズ集

    • URL

      http://www.kpu.ac.jp/cmsfiles/contents/0000001/1645/13.pdf

    • Related Report
      2012 Annual Research Report
  • [Remarks] 研究室HP

    • URL

      http://www2.kpu.ac.jp/life_environ/poly_mat_design/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www2.kpu.ac.jp/life_environ/poly_mat_design/index.html

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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