| Project/Area Number |
23655151
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Chemistry related to living body
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAI Hulin 筑波大学, 数理物質系, 特任助教 (40512554)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | ヘムタンパク質 / ヘム電子構造 / 計算化学 / NMR / 機能解析 / π-π相互作用 タンパク質の高次構造 / マリケン電荷 / π-π相互作用 / タンパク質の高次構造 / ＮＭＲ |
|---|
| Research Abstract |
Hemoglobin is the heme-containing oxygen-transport protein in the red blood cell. Highly efficient oxygen-transport of hemoglobin is achieved by cooperative oxygen binding properties of the protein. In this study, molecular mechanism responsible for the cooperative oxygen binding of the protein has been investigated from the standpoint of a novel theory, i.e., the electron theory of the heme cofactor. The study revealed that electronic interaction among the heme π-system, the heme iron, and the F-bound histidine plays a crucial role in control of the cooperative oxygen binding of the protein.
|
