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Narrow-bandwidth intensity noise suppression through the interference of neighboring pulses for nonlinear-opticallock-in microscopy

Research Project

Project/Area Number 23656048
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied optics/Quantum optical engineering
Research InstitutionOsaka University

Principal Investigator

ITOH Kazuyoshi  大阪大学, 大学院・工学研究科, 教授 (80113520)

Co-Investigator(Kenkyū-buntansha) OZEKI Yasuyuki  大阪大学, 大学院・工学研究科, 助教 (60437374)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsレーザー / 雑音 / 誘導ラマン散乱 / 顕微鏡 / 光雑音 / ファイバーレーザー / 非線形光学 / 強度雑音 / 誘導ラマン散乱顕微鏡 / 生体顕微鏡
Research Abstract

We demonstrated a technique for reducing the photocurrent noise of fiber laser pulses based on a delay-and-add line. The noise was reduced down to the shot noise level. We then applied this technique to stimulated Raman scattering microscopy which exploits lock-in detection for label-free biological imaging. As a result, we achieved real-time imaging of polymer beads at an imaging speed of 0.4 s/frame.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (21 results) Remarks (2 results)

  • [Journal Article] Sensitivity enhancement of fiber-laser-based stimulated Raman scattering microscopy by collinear balanced detection technique2012

    • Author(s)
      Keisuke Nose, Yasuyuki Ozeki, Tatsuya Kishi, Kazuhiko Sumimura, Norihiko Nishizawa, Kiichi Fukui, Yasuo Kanematsu, and Kazuyoshi Itoh
    • Journal Title

      Optics Express

      Volume: vol.20,no.13 Pages: 13958-13965

    • Related Report
      2012 Final Research Report
  • [Journal Article] Sensitivity enhancement of fiber-laser-based stimulated Raman scattering microscopy by collinear balanced detection technique2012

    • Author(s)
      Keisuke Nose
    • Journal Title

      Optics Express

      Volume: 20 Issue: 13 Pages: 13958-13965

    • DOI

      10.1364/oe.20.013958

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] A fiber-laser-based stimulated Raman scattering spectral microscope2013

    • Author(s)
      Keisuke Nose, Yasuyuki Ozeki, Tatsuya Kishi, Kazuhiko Sumimura, Yasuo Kanematsu, and Kazuyoshi Itoh
    • Organizer
      Photonics West 2013
    • Year and Date
      2013-02-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 誘導ラマン散乱顕微鏡用ファイバー光源におけるパルスの高強度化と雑音特性の検討2012

    • Author(s)
      岸達也, 能勢啓輔, 小関泰之, 兼松泰男, 伊東一良
    • Organizer
      Optics & Photonics Japan 2012 (OPJ 2012)
    • Year and Date
      2012-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] ファイバー光源による誘導ラマン散乱分光顕微鏡2012

    • Author(s)
      能勢啓輔, 小関泰之, 岸達也, 住村和彦, 兼松泰男, 伊東一良
    • Organizer
      Optics & Photonics Japan 2012 (OPJ 2012)
    • Year and Date
      2012-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Sensitivity enhancement of Fiber-laser-based stimulated Raman scattering microscopy by intensity noisesuppressor2012

    • Author(s)
      Keisuke Nose, Yasuyuki Ozeki, Tatsuya Kishi, Kazuhiko Sumimura, Norihiko Nishizawa, Yasuo Kanematsu, and Kazuyoshi Itoh
    • Organizer
      CLEO 2012
    • Place of Presentation
      San Jose
    • Year and Date
      2012-05-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 同軸型バランスド検出法と高調波同期法を用いたファイバーレーザーベース誘導ラマン散乱顕微鏡2012

    • Author(s)
      能勢啓輔,小関泰之,岸 達也,住村和彦,西澤典彦,兼松泰男,伊東一良
    • Organizer
      第59回応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2012-03-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 同軸型バランスド検出法と高調波同期法を用いたファイバーレーザーベース誘導ラマン散乱顕微鏡2012

    • Author(s)
      能勢啓輔,小関泰之,岸 達也,住村和彦,西澤典彦,兼松泰男,伊東一良
    • Organizer
      応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 誘導ラマン散乱顕微鏡によるバイオイメージング2011

    • Author(s)
      小関泰之、伊東一良
    • Organizer
      秋季応用物理学会シンポジウム「ラマン分光技術の急展開:革新と波及」(招待講演)
    • Place of Presentation
      山形大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 誘導ラマン散乱による生体の顕微イメージング2011

    • Author(s)
      小関泰之、伊東一良
    • Organizer
      光波シンセシス研究グループ第18回研究会(招待講演)
    • Place of Presentation
      神戸大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 誘導ラマン散乱を用いた生体顕微法2011

    • Author(s)
      小関泰之、伊東一良
    • Organizer
      電子情報通信学会ソサイエティ大会(招待講演)
    • Place of Presentation
      北海道大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 誘導ラマン散乱を用いた生体顕微鏡の開発2011

    • Author(s)
      小関泰之、伊東一良
    • Organizer
      日本分光学会関西支部 ・日本分光学会赤外ラマン分光部会シンポジウム(招待講演)
    • Place of Presentation
      大阪電気通信大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 非線形光学顕微鏡による生きた細胞の低侵襲 3 次元イメージング2011

    • Author(s)
      伊東 一良,小関 泰之
    • Organizer
      OPJ2011, シンポジウム「デジタルオプティックシステム ―3D 計測から可視化・ストレージまで―」(招待講演)
    • Place of Presentation
      大阪大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 誘導ラマン散乱を用いる生体顕微鏡システム2011

    • Author(s)
      小関泰之、伊東一良
    • Organizer
      量子エレクトロニクス研究会「非線形光学50年 その基礎と材料・デバイスおよび応用」(招待講演)
    • Place of Presentation
      軽井沢
    • Related Report
      2011 Research-status Report
  • [Presentation] 誘導ラマン散乱顕微法のためのピコ秒パルスファイバーレーザーの高調波同期2011

    • Author(s)
      能勢啓輔,小関泰之,岸達也,住村和彦,兼松泰男,伊東一良
    • Organizer
      秋季応用物理学会
    • Place of Presentation
      山形大学
    • Related Report
      2011 Research-status Report
  • [Presentation] ファイバーレーザー誘導ラマン散乱顕微鏡のためのファイバー遅延線による同軸型バランス検出法

    • Author(s)
      能勢啓輔,小関泰之,岸 達也,兼松泰男,伊東一良
    • Organizer
      応用物理学会
    • Place of Presentation
      松山
    • Related Report
      2012 Final Research Report
  • [Presentation] ファイバーレーザー誘導ラマン散乱顕微鏡のためのファイバー遅延線による同軸型バランス検出法

    • Author(s)
      能勢啓輔
    • Organizer
      応用物理学会14a-B2-1
    • Place of Presentation
      愛媛大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 誘導ラマン散乱顕微鏡用ファイバー光源におけるパルスの高強度化と雑音特性の検討

    • Author(s)
      岸達也
    • Organizer
      Optics & Photonics Japan 2012 (OPJ 2012), 25aA6
    • Place of Presentation
      船橋
    • Related Report
      2012 Annual Research Report
  • [Presentation] ファイバー光源による誘導ラマン散乱分光顕微鏡

    • Author(s)
      能勢啓輔
    • Organizer
      Optics & Photonics Japan 2012 (OPJ 2012), 25aA7
    • Place of Presentation
      船橋
    • Related Report
      2012 Annual Research Report
  • [Presentation] Sensitivity enhancement of Fiber-laser-based stimulated Raman scattering microscopy by intensity noise suppressor

    • Author(s)
      Keisuke Nose
    • Organizer
      CLEO 2012, JW3G.7
    • Place of Presentation
      サンノゼ
    • Related Report
      2012 Annual Research Report
  • [Presentation] A fiber-laser-based stimulated Raman scattering spectral microscope

    • Author(s)
      Keisuke Nose
    • Organizer
      Photonics West 2013,paper 8588-35
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Extended wavelength tunability of a picosecond pulse source by double-pass spectral filter for fiber-laser-based stimulated Raman spectral microscopy

    • Author(s)
      Keisuke Nose
    • Organizer
      CLEO2013, CTu2M.1
    • Place of Presentation
      サンノゼ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Fiber-laser-based stimulated Raman microspectroscopy with shot-noise limited sensitivity

    • Author(s)
      Keisuke Nose
    • Organizer
      CLEO-PR2013, TuF4-2
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www-photonics.mls.eng.osaka-u.ac.jp

    • Related Report
      2012 Final Research Report
  • [Remarks] 大阪大学大学院工学研究科生命先端工学専攻フォトニック情報工学領域

    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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