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Development ofporous multi-layer biomaterial and basic study on regeneration of cartilage-bone multi-layer tissue

Research Project

Project/Area Number 23656090
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Materials/Mechanics of materials
Research InstitutionKyushu University

Principal Investigator

TODO Mitsugu  九州大学, 応用力学研究所, 准教授 (80274538)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords生体材料 / 再生医療 / 整形外科 / 組織工学 / 関節組織 / 生体力学 / 幹細胞
Research Abstract

The primary aim of this study was to develop multi-layer scaffolds having biomechanical compatibility with natural cartilage-bone layered tissue in order to apply to regenerative medicine for large scale injuries of joints. Fundamental fabrication process for regenerated artificial bone tissue was also tried to be established. Novel bioabsorbable multi-layer porous materials imitating the mechanical properties of cartilage-bone layered tissue was successfully developed by using biodegradable polymers such as PCL and PLLA with bioceramic HA. It was found that the compressive properties of the layered scaffolds are very similar to those of natural layered tissues. Regenerated artificial bone tissues have also developed by culturing mesenchymal stem cells with organic/inorganic composite scaffold for a certain period.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (30 results)

All 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (18 results) (of which Invited: 1 results)

  • [Journal Article] Biomechanical effect of implantation of chitosan/MWNTs reinforced scaffold into damaged femur2013

    • Author(s)
      Sunghyen Hwang and Mitsugu Todo
    • Journal Title

      Journal of Novel Carbon Resource Science

      Volume: 7 Pages: 1-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Compressive deformation behavior of bioabsorbable porous layered composite materials ofr articular tissue eigineering2013

    • Author(s)
      Sunghyen Hwang and Mitsugu Todo
    • Journal Title

      Journal of Solid Mechanics and Materials Engineering

      Volume: 7(2) Pages: 1-10

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and characterization of poly(ε-caprolactone) reinforced porous hydroxyapatite for bone tissue engineering2013

    • Author(s)
      Phanny Yos and Mitsugu Todo
    • Journal Title

      Key Engineering Materials

      Volume: 529-530 Pages: 447-452

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biomechanical effect of implantation of chitosan/MWNTs reinforced scaffold into damaged femur2013

    • Author(s)
      Sunghyen Hwang, Mitsugu Todo
    • Journal Title

      Journal of Novel Carbon Resource Sciences

      Volume: 7 Pages: 1-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compressive deformation behavior of bioabsorbable porous layered composite materials ofr articular tissue eigineering2013

    • Author(s)
      Sunghyen Hwang, Mitsugu Todo
    • Journal Title

      Journal of Solid Mechanics and Materials Engineering

      Volume: 7 Pages: 1-10

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of compressive deformation behavior of multi-layer porous composite materials for articular tissue engineering2012

    • Author(s)
      Sunghyen Hwang and Mitsugu Todo
    • Journal Title

      Journal of Mechanical Science and Technology

      Volume: 26(7) Pages: 1999-2004

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] コラーゲン/β-TCP複合系scaffoldの圧縮力学特性に及ぼす間葉系幹細胞培養の影響2012

    • Author(s)
      荒平高章,東藤 貢
    • Journal Title

      臨床バイオメカニクス

      Volume: 33 Pages: 237-244

    • NAID

      40019481020

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 多孔質バイオセラミックス人工骨の圧縮力学特性に及ぼすコラーゲンコーティングの影響2012

    • Author(s)
      荒平高章,東藤 貢
    • Journal Title

      粉体および粉末冶金

      Volume: 59(7) Pages: 421-424

    • NAID

      10030992959

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of compressive deformation behavior of multi-layer porous composite materials for articular tissue engineering2012

    • Author(s)
      Sunghyen Hwang, Mitsugu Todo
    • Journal Title

      Journal of Mechanical Science and Technology

      Volume: 26 Pages: 1999-2004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 多孔質バイオセラミックス人工骨の圧縮力学特性に及ぼすコラーゲンコーティングの影響2012

    • Author(s)
      荒平高章,東藤 貢
    • Journal Title

      粉体および粉末冶金

      Volume: 59 Pages: 421-424

    • NAID

      10030992959

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Compressive Deformation Behavior of Multi-layer Porous Composite Materials for Articular Tissue Engineering2012

    • Author(s)
      Sunghyen Hwang and Mistugu Todo
    • Journal Title

      Journal of Mechanical Science and Technology

      Volume: 未定

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development and characterization of reinforced poly(L-lactide) scaffolds for bone tissue Engineering2011

    • Author(s)
      J.E.Park, M.Todo
    • Journal Title

      Journal of Materials Science : Materials in Medicine

      Volume: 22 Issue: 5 Pages: 1171-1182

    • DOI

      10.1007/s10856-011-4289-4

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 有機・無機2相多孔質構造体と間葉系幹細胞を用いた骨再生に関する基礎的研究2013

    • Author(s)
      東藤貢,荒平高章,名井陽
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2013-03-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 構造が異なる 2 種類の複合系足場材を用いた骨髄由来間葉系幹細胞の培養と増殖・分化・ECM形成能の比較2013

    • Author(s)
      東藤貢,荒平高章,名井陽
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2013-03-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨組織工学のための有機・無機 2 相多孔質材料の創製と評価2013

    • Author(s)
      荒平高章,東藤貢
    • Organizer
      第25回バイオエンジニアリング講演会
    • Place of Presentation
      つくば市
    • Year and Date
      2013-01-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨組織工学のための有機・無機2相多孔質材料の創製と評価2013

    • Author(s)
      荒平高章,東藤貢
    • Organizer
      第25回バイオエンジニアリング講演会
    • Place of Presentation
      産業技術総合研究所つくばセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] コラーゲンゲル・多孔体2相scaffoldによる軟骨再生の基礎的研究2013

    • Author(s)
      東藤貢,中牟田侑昌
    • Organizer
      第25回バイオエンジニアリング講演会
    • Place of Presentation
      産業技術総合研究所つくばセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] β-TCP/collagen scaffold の圧縮特性に及ぼす間葉系幹細胞培養の影響2012

    • Author(s)
      荒平高章,東藤貢,名井陽
    • Organizer
      第39回日本臨床バイオメカニクス学会
    • Place of Presentation
      千葉市
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨組織工学用多孔質HAp/PCL複合材料の力学特性2012

    • Author(s)
      Yos Phanny, 東藤貢
    • Organizer
      日本機械学会M&M2012材料力学カンファレンス
    • Place of Presentation
      愛媛大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] コラーゲン/β-TCP複合系scaffoldを用いた間葉系幹細胞培養系における細胞外マトリックス形成機構2012

    • Author(s)
      東藤貢,荒平高章
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 軟骨・骨インターフェイス組織再生のための多層scaffoldの圧縮変形挙動2012

    • Author(s)
      Hwang SungHyen,東藤貢
    • Organizer
      第25回バイオエンジニアリング講演会
    • Place of Presentation
      大阪大学(豊中市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Characterization of compressive deformation behavior of multi-layer porous composite materials for articular tissue engineering2011

    • Author(s)
      Sunghyen Hwang and Mitsugu Todo
    • Organizer
      International Conference on Materials and Reliability 2011
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2011-11-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of polymer/composite multi-layer porous material for osteochondral tissue engineering2011

    • Author(s)
      Sunghyen Hwang and Mitsugu Todo
    • Organizer
      The 8thKorea-Japan Joint Symposium on Composite Materials
    • Place of Presentation
      Changwon, Korea.
    • Year and Date
      2011-11-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 関節組織再生のための積層構造 scaffold の圧縮変形挙動2011

    • Author(s)
      Hwang Sunghyen,東藤貢
    • Organizer
      日本機械学会材料力学講演会(M&M2011)
    • Place of Presentation
      北九州市
    • Year and Date
      2011-07-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 軟骨・骨インターフェイス組織再生のための多層scaffold の圧縮変形挙動2011

    • Author(s)
      Hwang Sunghyen, 東藤貢
    • Organizer
      日本機械学会第24回バイオエンジニアリング講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-01-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 関節組織再生のための積層構造scaffoldの圧縮変形挙動2011

    • Author(s)
      Hwang SungHyen,東藤貢
    • Organizer
      M&M2011材料力学カンファレンス
    • Place of Presentation
      九州工業大学(北九州市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of multi-layer composite scaffold for articular regeneration2011

    • Author(s)
      SungHyen Hwang, Mitsugu Todo
    • Organizer
      The 18th International Conference on Composite Materials
    • Place of Presentation
      Jeju, KOREA
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of polymer/composite multi-layer porous material for osteochondral tissue engineering2011

    • Author(s)
      SungHyen Hwang, Mitsugu Todo
    • Organizer
      8th Korea-Japan Joint Symposium on Composite Materials
    • Place of Presentation
      Changwon, KOREA
    • Related Report
      2011 Research-status Report
  • [Presentation] Characterization of compressive deformation behavior of multi-layer porous composte materials for articular tissue engineering2011

    • Author(s)
      SungHyen Hwang, Mitsugu Todo
    • Organizer
      International Conference on Materials and Reliability 2011
    • Place of Presentation
      Busan, KOREA
    • Related Report
      2011 Research-status Report
  • [Presentation] 有機・無機複合系多孔質材料と間葉系幹細胞を用いたin vitroでの骨組織形成

    • Author(s)
      東藤貢
    • Organizer
      第16回バイオレオロジー・リサーチ・フォーラム
    • Place of Presentation
      東京大学医学部
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2011-08-05   Modified: 2019-07-29  

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