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Exploration of Optimum Conditions for Sonoporation Effect by Controlling Multi-Phase Flow Field with Microscopic Visualization

Research Project

Project/Area Number 23656124
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Fluid engineering
Research InstitutionHokkaido University of Education

Principal Investigator

TOMITA Yukio  北海道教育大学, 教育学部, 教授 (00006199)

Co-Investigator(Kenkyū-buntansha) MATSUURA Toshihiko  北海道教育大学, 教育学部, 准教授 (50431383)
KODAMA Tetsuya  東北大学, 医工学研究科, 教授 (40271986)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsマイクロバブル / キャビテーション / ソノポレーション / 超音波 / 分子導入 / マイクロジェット / 衝撃波 / 気泡
Research Abstract

A fine liquid jet was produced during the collapse of individual small gas bubbles in the second collapse of an attached Sonazoid microbubble. Evidential pits are found on the gel surface. Nanoscale pits are dominant in 0.01 s < T_<ex> < 1 s, and caused by the collapse of Sonazoid microbubbles, whereas microscale pits in T_<ex> > 1 s mainly resulted from cavitation. We found the maximum number of pits when a moderate pressure amplitude of 0.45 MPa was applied, together with a duty ratio of 0.1 and 20 pulses, a result that nearly equals that obtained by continuous ultrasound at a pressure of 0.75 MPa. These results suggests that more suitable conditions for sonoporation can be determined by systematically exploring the characteristics of ultrasound.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 2 results) Presentation (17 results)

  • [Journal Article] 集束超音波とソナゾイドの干渉による寒天壁の微視的観察2013

    • Author(s)
      松浦俊彦、冨田幸雄, 他2名
    • Journal Title

      日本産業技術教育学会北海道支部会研究論文集

      Volume: 26号 Pages: 17-20

    • Related Report
      2012 Final Research Report
  • [Journal Article] 集束超音波による寒天壁の表面損傷に及ぼすキャビテーション効果2013

    • Author(s)
      松浦俊彦、冨田幸雄, 他2名
    • Journal Title

      日本産業技術教育学会北海道支部会研究論文集

      Volume: 26号 Pages: 13-16

    • Related Report
      2012 Final Research Report
  • [Journal Article] 集束超音波による寒天壁の表面損傷に及ぼすキャビテーション効果2013

    • Author(s)
      岡田 昭
    • Journal Title

      日本産業技術教育学会北海道支部会研究論文集

      Volume: 第26号 Pages: 13-16

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 集束超音波とソナゾイドの干渉による寒天壁の微視的観察2013

    • Author(s)
      田仲 慈訓
    • Journal Title

      日本産業技術教育学会北海道支部会研究論文集

      Volume: 第26号 Pages: 17-20

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Characteristics of Sonazoid destruction and bubble motion caused by focused ultrasound2012

    • Author(s)
      Yukio Tomita, Shigenori Tanaka and Tetsuya Kodama
    • Journal Title

      Proceedings of the 8^<th> International Symposium on Cavitation、CAV2012

      Volume: No.31 Pages: 119-124

    • DOI

      10.3850/978-981-07-2826-7_031

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Focused ultrasound induced free-surface breakup and damage in acrylic plates2012

    • Author(s)
      Yukio Tomita and Shigenori Tanaka
    • Journal Title

      AIP Conference Proceedings

      Volume: Vol.1474 Pages: 123-126

    • DOI

      10.1063/1.4749311

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 集束超音波によるソナゾイド破壊の高倍率光学観察2012

    • Author(s)
      冨田幸雄、田仲慈訓
    • Journal Title

      日本産業技術教育学会北海道支部会研究論文集

      Volume: 25号 Pages: 15-18

    • Related Report
      2012 Final Research Report
  • [Journal Article] 集束超音波によるソナゾイド破壊の高倍率光学観察2012

    • Author(s)
      冨田幸雄
    • Journal Title

      日本産業技術教育学会北海道支部会研究論文集

      Volume: 第25号 Pages: 15-18

    • Related Report
      2011 Research-status Report
  • [Presentation] 集束超音波とソナゾイドの干渉による気泡のダイナミックスと寒天ゲル表面の微視的観察2012

    • Author(s)
      冨田幸雄
    • Organizer
      キャビテーションに関するシンポジウム(第16回)
    • Place of Presentation
      金沢工業大学(野々市)
    • Year and Date
      2012-11-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 超音波作用による寒天壁近傍でのソナゾイドの破壊と気泡のダイナミックス2012

    • Author(s)
      冨田幸雄
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢大学(金沢)
    • Year and Date
      2012-09-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Characteristics of Sonazoid destruction and bubble motion caused by focused ultrasound2012

    • Author(s)
      Yukio Tomita
    • Organizer
      Presented at the 8^<th> International Symposium on Cavitation
    • Place of Presentation
      Novotel Singapore Clarke Quay、Singapore
    • Year and Date
      2012-08-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Focused ultrasound induced free-surface breakup and damage in acrylic plates2012

    • Author(s)
      Yukio Tomita
    • Organizer
      Presented at the 19^<th> International Symposium on Nonlinear Acoustics
    • Place of Presentation
      Waseda University、Japan
    • Year and Date
      2012-05-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Ultrasound induced Sonazoid destruction and the resultant bubble motion2011

    • Author(s)
      Yukio Tomita
    • Organizer
      Presented at the informal meeting as a part of Joint Research Project under the Japan-Korea Basic Scientific Cooperation Program for FY 2009
    • Place of Presentation
      Jeju National University、Republic of Korea
    • Year and Date
      2011-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 集束超音波によるソナゾイドの破壊と気泡生成2011

    • Author(s)
      冨田幸雄
    • Organizer
      日本機械学会2011年度年次大会
    • Place of Presentation
      東京工業大学(東京)
    • Year and Date
      2011-09-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 集束超音波による水面近傍のアクリル板の変形と破壊2011

    • Author(s)
      冨田幸雄
    • Organizer
      日本混相流学会年会講演会2011
    • Place of Presentation
      京都工芸繊維大学(京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 集束超音波によるソナゾイドの破壊と気泡生成2011

    • Author(s)
      冨田幸雄
    • Organizer
      日本機械学会2011年度年次大会
    • Place of Presentation
      東京工業大学(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] Ultrasound induced Sonazoid destruction and the resultant bubble motion2011

    • Author(s)
      Y.Tomita
    • Organizer
      Informal meeting as a part of Joint Research Project under the Japan-Korea Basic Scientific Cooperation Program for FY 2009
    • Place of Presentation
      Jeju National University, Republic of Korea
    • Related Report
      2011 Research-status Report
  • [Presentation] 集束超音波によるソナゾイド破壊の高倍率光学観察2011

    • Author(s)
      田仲慈訓
    • Organizer
      日本産業技術教育学会北海道支部会第25回大会
    • Place of Presentation
      北海道教育大学札幌駅前サテライト(札幌)
    • Related Report
      2011 Research-status Report
  • [Presentation] Focused ultrasound induced free-surface breakup and damage in acrylic plates

    • Author(s)
      Y.Tomita
    • Organizer
      19th International Symposium on Nonlinear Acoustics
    • Place of Presentation
      International Conference Center of Waseda University, Tokyo
    • Related Report
      2012 Annual Research Report
  • [Presentation] 集束超音波の界面現象およびDDS基礎研究への応用

    • Author(s)
      冨田 幸雄
    • Organizer
      日本機械学会北海道支部平成24年度第1回流体懇話会
    • Place of Presentation
      北海道大学(札幌)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Characteristics of Sonazoid destruction and bubble motion caused by focused ultrasound

    • Author(s)
      Y.Tomita
    • Organizer
      8th International Symposium on Cavitation, CAV2012
    • Place of Presentation
      Novotel Singapore Clarke Quay, Singapore
    • Related Report
      2012 Annual Research Report
  • [Presentation] 超音波作用による寒天壁近傍でのソナゾイドの破壊と気泡のダイナミックス

    • Author(s)
      冨田 幸雄
    • Organizer
      日本機械学会2012年次大会
    • Place of Presentation
      金沢大学(金沢)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 集束超音波による寒天壁の表面損傷に及ぼすキャビテーション効果

    • Author(s)
      岡田 昭
    • Organizer
      日本産業技術教育学会北海道支部会第26回大会
    • Place of Presentation
      北海道教育大学札幌駅前サテライト(札幌)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 集束超音波とソナゾイドの干渉による寒天壁の微視的観察

    • Author(s)
      田仲 慈訓
    • Organizer
      日本産業技術教育学会北海道支部会第26回大会
    • Place of Presentation
      北海道教育大学札幌駅前サテライト(札幌)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 集束超音波とソナゾイドの干渉による気泡のダイナミックスと寒天ゲル表面の微視的観察

    • Author(s)
      冨田 幸雄
    • Organizer
      キャビテーションに関するシンポジウム(第16回)
    • Place of Presentation
      金沢工業大学(野々市)
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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