Exploration of Optimum Conditions for Sonoporation Effect by Controlling Multi-Phase Flow Field with Microscopic Visualization
| Project/Area Number |
23656124
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fluid engineering
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| Research Institution | Hokkaido University of Education |
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Principal Investigator |
TOMITA Yukio 北海道教育大学, 教育学部, 教授 (00006199)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUURA Toshihiko 北海道教育大学, 教育学部, 准教授 (50431383)
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | マイクロバブル / キャビテーション / ソノポレーション / 超音波 / 分子導入 / マイクロジェット / 衝撃波 / 気泡 |
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| Research Abstract |
A fine liquid jet was produced during the collapse of individual small gas bubbles in the second collapse of an attached Sonazoid microbubble. Evidential pits are found on the gel surface. Nanoscale pits are dominant in 0.01 s < T_<ex> < 1 s, and caused by the collapse of Sonazoid microbubbles, whereas microscale pits in T_<ex> > 1 s mainly resulted from cavitation. We found the maximum number of pits when a moderate pressure amplitude of 0.45 MPa was applied, together with a duty ratio of 0.1 and 20 pulses, a result that nearly equals that obtained by continuous ultrasound at a pressure of 0.75 MPa. These results suggests that more suitable conditions for sonoporation can be determined by systematically exploring the characteristics of ultrasound.
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Report
(3 results)
Research Products
(25 results)
