Seamless Single Cell Sorting Method Appropriately Appling Shear Flows and Distorted Electric Fields
| Project/Area Number |
23656136
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fluid engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TATSUMI Kazuya 京都大学, 大学院・工学研究科, 准教授 (90372854)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 単細胞選別 / 流体計測 / せん断流れ / 電場強度分布 / 誘電泳動力 / 静電泳動力 |
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| Research Abstract |
Numerical simulation and flow visualization on the motions of a fine spherical polystyrene particle in a microchannel installing thin membrane-type electrodes were made in order to develop an innovative method for fast and seamless sorting of single cell, in particular, red blood cell (RBC). Distorted electric fields around straight- or semi-circle- type electrodes that dielectrophoretic (DEP) forces suitably act on the particle flowing in the channel were numerically predicted. The numerically obtained trajectories of the particles show the good agreement with the visualization results, which can be expected to advance an effective manipulation and sorting of RBCs using DEP.
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Report
(3 results)
Research Products
(33 results)
