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System Biology Model for Tumor Radiotherapy

Research Project

Project/Area Number 23656170
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionHokkaido University

Principal Investigator

TADANO Shigeru  北海道大学, 大学院・工学研究院, 教授 (50175444)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsバイオメカニクス / システムバイオロジー / 力学アナロジー / 放射線治療モデル / シミュレーション
Research Abstract

This study is to propose a computational simulation method to calculate therapeuticoutcomes in radiotherapy, and also applied a method of system biology. As a tumor shrinksdue to radiation exposure, it was possible to express the radiotherapeutic effects in terms oftumor volume changes and geometric distortion. The shrinking was assumed to expressmechanical analogy of solid body. The relationships between radiation energy and tumordeformation were estimated from solid mechanics equations. Finite element models oftumors were constructed based on computed tomography (CT) images. Some values ofparameters prescribing tumor radiosensitivity or growth rates of tumor cells wereidentified so that the calculated results fit the clinical results. Simulation results will showthat the simulation model can be applied to a variety of clinical cases by determining thetumor parameters appropriately.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Computer Simulation and Analysis of Three-Dimensional Tumor Geometry in Radiotherapy2013

    • Author(s)
      S. Takao, S. Tadano, H. Taguchi, H. Shirato
    • Journal Title

      Applied Biological Engineering-Principles and Practice

      Volume: 662 Pages: 29-46

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Computer Simulation and Analysis of Three-Dimensional Tumor Geometry in Radiotherapy2013

    • Author(s)
      Seishin Takao
    • Journal Title

      Applied Biological Engineering - Principles and Practice

      Volume: 662 Pages: 29-46

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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