| Project/Area Number |
23656170
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Intelligent mechanics/Mechanical systems
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| Research Institution | Hokkaido University |
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Principal Investigator |
TADANO Shigeru 北海道大学, 大学院・工学研究院, 教授 (50175444)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | バイオメカニクス / システムバイオロジー / 力学アナロジー / 放射線治療モデル / シミュレーション |
|---|
| Research Abstract |
This study is to propose a computational simulation method to calculate therapeuticoutcomes in radiotherapy, and also applied a method of system biology. As a tumor shrinksdue to radiation exposure, it was possible to express the radiotherapeutic effects in terms oftumor volume changes and geometric distortion. The shrinking was assumed to expressmechanical analogy of solid body. The relationships between radiation energy and tumordeformation were estimated from solid mechanics equations. Finite element models oftumors were constructed based on computed tomography (CT) images. Some values ofparameters prescribing tumor radiosensitivity or growth rates of tumor cells wereidentified so that the calculated results fit the clinical results. Simulation results will showthat the simulation model can be applied to a variety of clinical cases by determining thetumor parameters appropriately.
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