CMOS-based flexible brain stimulation / measurement device

• Project/Area Number: 23656241
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Electron device/Electronic equipment
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: TOKUDA Takashi 奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (50314539)
• Co-Investigator(Renkei-kenkyūsha): OHTA Jun 奈良先端科学技術大学院大学, 物質創成科学研究科, 教授 (80304161) ; SASAGAWA Kiyotaka 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (50392725) ; NODA Toshihiko 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (20464159)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: バイオデバイス / バイオセンシング / 脳刺激計測 / CMOS / 生体埋め込みデバイス

Research Abstract

A CMOS-based implantable flexible neural stimulation / measurement device was proposed and demonstrated. The most important feature of the device is its "Multi-chip architecture".
We design a small-sized, intelligent neural interface devices ("Unit chip") and aligned them on a flexible substrate. It enables a neural stimulation / measurement device with intelligent functionality and flexibility to fit a curved tissue.We designed a CMOS unit chip and fabricated a flexible neural stimulation / measurement device for feasibility study, and obtained promising results.

Research Products

• [Journal Article] Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips (2014)
  • Author(s): T. Noda, K. Sasagawa, T. Tokuda, Y. Terasawa, H. Takashiro, H. Kanda, T. Fujikado, and J. Ohta
  • Journal Title: Sensors and Actuators A : Physcal Volume: 211 Pages: 27-37
  • Peer Reviewed
• [Journal Article] Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips (2014)
  • Author(s): T. Noda, K. Sasagawa, T. Tokuda, Y. Terasawa, H. Takashiro, H. Kanda, T. Fujikado, and J. Ohta
  • Journal Title: Sensors and Actuators A: Physcal Volume: 211 Pages: 27-37
  • DOI: 10.1016/j.sna.2014.03.001
  • Peer Reviewed
• [Journal Article] A CMOS optoelectronic neural interface device based on an image sensor with on-chip light stimulation and extracellular neural signal recording for optogenetics (2013)
  • Author(s): Y. Sawadsaringkarn, T. Miyatani, T. Noda, K. Sasagawa, T. Tokuda, and J. Ohta
  • Journal Title: ITE Transactions on Media Technology and Applications Volume: 1(2) Pages: 184-189
  • Peer Reviewed
• [Journal Article] Sputtering Condition Optimization of Sputtered IrOx and TiN Stimulus Electrodes for Retinal Prosthesis (2013)
  • Author(s): Yi-Li Pan, T. Noda, K. Sasagawa, T. Tokuda, and J. Ohta
  • Journal Title: IEEJ Transaction on Electrical and Electronic Engineering Volume: 8(3) Pages: 310-312
  • Peer Reviewed
• [Journal Article] A Smart Electrode Array Device with CMOS Multi-Chip Architecture for Neural Interface (2012)
  • Author(s): T. Noda, K. Sasagawa, T. Tokuda, Y. Terasawa, H. Tashiro, H. Kanda, T. Fujikado and J. Ohta
  • Journal Title: Electronics Letters Volume: 48(21) Pages: 1328-1329
  • Peer Reviewed
• [Presentation] CMOS ベースマイクロバイオメディカルフォトニックデバイスの研究開発 (2014)
  • Author(s): 徳田 崇, 他
  • Organizer: 電子情報通信学会総合大会
  • Place of Presentation: 新潟大学五十嵐キャンパス
  • Year and Date: 2014-03-20
  • Invited
• [Presentation] AC 駆動型人工視覚向け網膜刺激デバイスの駆動検証 (2014)
  • Author(s): 藤沢 匠, 他
  • Organizer: 応用物理学会春季学術講演会
  • Place of Presentation: 青山学院大学相模原キャンパス
  • Year and Date: 2014-03-17
• [Presentation] CMOS イメージセンサをベースとした生体埋め込みデバイス (2014)
  • Author(s): 徳田 崇, 他
  • Organizer: 集積光デバイスと応用技術時限研究専門委員会
  • Place of Presentation: 鬼怒川温泉ホテル
  • Year and Date: 2014-01-31
  • Invited
• [Presentation] CMOSベースマイクロバイオメディカルフォトニックデバイスの研究開発 (2014)
  • Author(s): 徳田 崇, 野田 俊彦, 笹川 清隆, 太田 淳
  • Organizer: 電子情報通信学会総合大会
  • Place of Presentation: 新潟大学 五十嵐キャンパス
  • Invited
• [Presentation] AC駆動型人工視覚向け網膜刺激デバイスの駆動検証 (2014)
  • Author(s): 藤沢 匠, 黒木 渉平, 石井 孔明, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
  • Organizer: 応用物理学会春季学術講演会
  • Place of Presentation: 青山学院大学相模原キャンパス
• [Presentation] CMOSイメージセンサをベースとした生体埋め込みデバイス (2014)
  • Author(s): 徳田 崇, 野田 俊彦, 笹川 清隆, 太田 淳
  • Organizer: 集積光デバイスと応用技術時限研究専門委員会
  • Place of Presentation: 鬼怒川温泉ホテル
  • Invited
• [Presentation] CMOS-based Bio- Implantable Neural Observation and Stimulation Device (2013)
  • Author(s): T. Tokuda
  • Organizer: International Workshop on Biomedical Engineering Translational Research
  • Place of Presentation: National Chiao Tung University, Hsinchu City, Taiwan
  • Year and Date: 2013-12-10
  • Invited
• [Presentation] Device Packaging of CMOS-Based Optoelectronic Neural Interface Device for in Vitro and in Vivo Optogenetics (2013)
  • Author(s): T. Tokuda, et al
  • Organizer: International IEEE EMBS Conference on Neural Engineering
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-07
• [Presentation] Intelligent Retinal Prosthetic Device Employs Smart Electrode Array Integrated with CMOS Microchips (2013)
  • Author(s): T. Noda, et al
  • Organizer: International Conference on BioSensors, BioElectronics, BioMedical Devices
  • Place of Presentation: BioMEMS/NEMS and Applications 2013
  • Year and Date: 2013-10-30
• [Presentation] CMOS チップ搭載型生体埋め込みデバイス-エレクトロニクスの新しいバイオ・医療応用に向けて (2013)
  • Author(s): 徳田 崇
  • Organizer: 応用物理学会関西支部平成25年度第2回講演会「関西のグリーン・バイオエレクトロニクス研究の現状と若手からの発信」
  • Place of Presentation: 奈良先端科学技術大学院大学
  • Year and Date: 2013-10-09
• [Presentation] Optoelectronics Devices for Biomedical Applications (2013)
  • Author(s): T. Tokuda
  • Organizer: The 10th Conference on Lasers and Electro-Optics Pacific Rim (CLEOPR2013)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2013-07-02
  • Invited
• [Presentation] Device Packaging of CMOS-Based Optoelectronic Neural Interface Device for in Vitro and in Vivo Optogenetics (2013)
  • Author(s): Takashi Tokuda, Shun Nakajima, Yasuyo Maezawa, Toshihiko Noda, Kiyotaka Sasagawa, Jun Ohta
  • Organizer: International IEEE EMBS Conference on Neural Engineering (NER2013)
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Intelligent Retinal Prosthetic Device Employs Smart Electrode Array Integrated with CMOS Microchips (2013)
  • Author(s): Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yasuo Terasawa, Hiroyuki Tashiro, Hiroyuki Kanda, Takashi Fujikado, Jun Ohta
  • Organizer: International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS and Applications 2013
  • Place of Presentation: Tokyo Medical and Dental University, Japan
• [Presentation] Optoelectronics Devices for Biomedical Applications (2013)
  • Author(s): Takashi Tokuda
  • Organizer: The 10th Conference on Lasers and Electro-Optics Pacific Rim(CLEO-PR 2013)
  • Place of Presentation: Kyoto International Conference Center, Kyoto, JAPAN
  • Invited
• [Presentation] CMOSチップ搭載型生体埋め込みデバイス－エレクトロニクスの新しいバイオ・医療応用に向けて－ (2013)
  • Author(s): 徳田 崇
  • Organizer: 応用物理学会関西支部平成25年度第2回講演会
  • Place of Presentation: 奈良先端科学技術大学院大学
• [Presentation] Microelectronics-based Implantable Devices for Bio-Medical ApplicationsMicroelectronics-based Implantable Devices for Bio-Medical Applications (2012)
  • Author(s): T. Tokuda
  • Organizer: IEEEPrimeAsia Conference 2012
  • Place of Presentation: Hyderabad, INDIA
  • Year and Date: 2012-12-06
• [Presentation] CMOS 技術を用いた生体埋め込み対応バイオデバイス (2012)
  • Author(s): 徳田 崇, 他
  • Organizer: 第25回回路とシステムワークショップ
  • Place of Presentation: 淡路夢舞台, 兵庫県
  • Year and Date: 2012-07-30
  • Invited
• [Presentation] CMOS チップを搭載した刺入型刺激・計測デバイスの作製 (2012)
  • Author(s): 東丸 幸江, 他
  • Organizer: 第59回応用物理学関係連合講演会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2012-03-16
  • Invited
• [Presentation] CMOSチップを搭載した刺入型刺激・計測デバイスの作製 (2012)
  • Author(s): 東丸 幸江 他
  • Organizer: 第59回 応用物理学関係連合講演会
  • Place of Presentation: 早稲田大学
• [Presentation] CMOS チップ搭載インテリジェント生体インターフェースデバイス (2011)
  • Author(s): 野田 俊彦, 他
  • Organizer: 電気学会E 部門バイオ・マイクロシステム研究会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2011-06-30
• [Presentation] CMOSチップ搭載インテリジェント生体インターフェースデバイス (2011)
  • Author(s): 野田 俊彦 他
  • Organizer: 電気学会E部門 バイオ・マイクロシステム研究会
  • Place of Presentation: 東京工業大学
• [Presentation] Fabrication of a Flexible Neural ... (2011)
  • Author(s): Toshihiko Noda 他
  • Organizer: VLSI-SoC2011
  • Place of Presentation: Royal Plaza Hotel, 香港
• [Presentation] CMOS-based Bio-Implantable Neural Observation and Stimulation Device
  • Author(s): T. Tokuda
  • Organizer: International Workshop on Biomedical Engineering Translational Research
  • Place of Presentation: National Chiao Tung University, Hsinchu City, Taiwan
  • Invited
• [Presentation] Microelectronics-based Implantable Devices for Bio-Medical Applications Microelectronics-based Implantable Devices for Bio-Medical Applications
  • Author(s): Takashi Tokuda
  • Organizer: IEEE PrimeAsia Conference 2012
  • Place of Presentation: Hyderabad, INDIA
  • Invited
• [Presentation] CMOS技術を用いた生体埋め込み対応バイオデバイス
  • Author(s): 徳田 崇, 野田 俊彦, 笹川 清隆, 太田 淳
  • Organizer: 第25回 回路とシステムワークショップ
  • Place of Presentation: 淡路夢舞台, 兵庫県
  • Invited