| Project/Area Number |
23656424
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Structural/Functional materials
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
HANAWA Takao 東京医科歯科大学, 生体材料工学研究所, 教授 (90142736)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NOMURA Naoyuki 東北大学, 大学院・工学研究科, 准教授 (90332519)
DOI Hisashi 東京医科歯科大学, 生体材料工学研究所, 助教 (30251549)
TSUTSUMI Yusuke 東京医科歯科大学, 生体材料工学研究所, 准教授 (60447498)
MIGITA Satoshi 山形大学, 大学院・理工学研究科, 助教 (00512302)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | チタン / 軟組織 / コラーゲン / 電着 / 固定化 / バイオマテリアル / 生体材料学 / 生体機能材料 / 生体適合材料 / バイオコンジュケート材料 / バイオコンジュゲート材料 |
|---|
| Research Abstract |
To immobilize collagen uniformly to titanium surface without self-assembly of collagen, electrodeposition technique with alternative current, repetition of anodic current and cathodic current charge, was the most effective. The soft tissue compatibility of titanium immobilized collagen was evaluated by cell culture of fibroblast. The results revealed that initial adhesion, expansion, and proliferation of cells were not inhibited on the surface. On the other hand, it was difficult to evaluate the bonding strength between soft tissue and substrate material. Further research to obtain reproducible and reliable evaluation of sft tissue compatibility protocol is necessary.
|
