Detection system for the influenza virus by novel functional polymer and artificial enzyme
| Project/Area Number |
23656495
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | The University of Kitakyushu |
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Principal Investigator |
UEZU Kazuya 北九州市立大学, 国際環境工学部, 教授 (40253497)
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| Co-Investigator(Kenkyū-buntansha) |
KAWANO Tomonori 北九州市立大学, 国際環境工学部, 准教授 (20335699)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 分子認識 / ウィルスセンサー / ポリマーブラシ / シグナル変換 / 分離精製 / 化学センサー / 環境分析 |
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| Research Abstract |
The hemagglutinin protein on influenza virus can recognize the sialic acid on the cell membrane, and the virus infects the human cell. In this study, we utilize this mechanism to prepare the functional membrane, which can detects the influenza virus. This functional membrane was prepared by radiation-induced graft polymerization. To immobilize the sialic acid as the recognition site of the hemagglutinin protein on the influenza virus, the coupled iminodiacetic acid and 1-ethyl-3-carbodiimide hydrochloride was introduced onto the porous hollow fiber membrane. Copper ion as a signal substance was adsorbed on the sialic acid immobilizesd porous hollow fiber membrane, and it indicated the possibility of the sensor for influenza virus.
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Report
(3 results)
Research Products
(6 results)
