• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Measurement of mechanical properties of the cell nucleus for an exhaustive evaluation of stem cell differentiation

Research Project

Project/Area Number 23656520
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biofunction/Bioprocess
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

MATUNAGA Tadashi  東京農工大学, 大学院・工学研究院, 学長 (10134834)

Co-Investigator(Kenkyū-buntansha) YOSHINO Tomoko  東京農工大学, 大学院・工学研究院, 准教授 (30409750)
Project Period (FY) 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywordsバイオセパレーション / 細胞・組織 / マイクロ・ナノデバイス
Research Abstract

In this study, the microcavity array which enables entrapment of 10, 000 single cells with high efficiency was utilized for the quantitative evaluation of cellular deformability. A quantitative measurement procedure of the three dimensional image of the cells trapped on the microcavity array by image analysis using the confocal microscopy was established. Using these techniques, cellular deformability of normal cells and cancer cells were quantitatively evaluated for considering the correlation between their deformability and progress degrees of differentiation or canceration.

Report

(2 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (6 results)

All 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Leukocyte Counting from a Small Amount of Whole Blood Using a Size-Controlled Microcavity Array2012

    • Author(s)
      Masahito Hosokawa
    • Journal Title

      Biotechnol.Bioeng.

      Volume: 109 Issue: 8 Pages: 2017-2024

    • DOI

      10.1002/bit.24471

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Microcavity arrayを用いた単一細胞集積化技術2012

    • Author(s)
      松永是
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶応義塾大学
    • Year and Date
      2012-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Microcavity arrayを用いた単一細胞集積化技術2012

    • Author(s)
      松永是
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学(招待講演)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 全血からの循環腫瘍細胞濃縮に向けたマイクロフィルター構造の最適化2011

    • Author(s)
      吉川貴之,細川正人,吉野知子,菊原得仁,上原寿茂,金久修,松永是
    • Organizer
      第63回生物工学会
    • Place of Presentation
      東京農工大学
    • Year and Date
      2011-09-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Bioelectrochemistry for Health, Environment and Energy2011

    • Author(s)
      Tadashi MATSUNAGA
    • Organizer
      62^<nd> annual meeting of the International Society of Electrochemistry
    • Place of Presentation
      朱鷺メッセ
    • Year and Date
      2011-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Bioelectrochemistry for Health, Environment and Energy2011

    • Author(s)
      Tadashi MATSUNAGA
    • Organizer
      62nd annual meeting of the International Society of Electrochemistry
    • Place of Presentation
      朱鷺メッセ(招待講演)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi