| Project/Area Number |
23657004
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Konan University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 線虫 / C. elegans / 温度応答 / 神経回路 / カルシウムイメージング / 線虫C. エレガンス / 情報識別 / 温度走性 / 匂い情報処理 / 分子遺伝学 |
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| Research Abstract |
To identify molecular and physiological mechanisms for discrimination of neuralinformation, we used simple local neural circuit underlying temperature sensation andprocessing. We utilized molecular genetics, behavioral analysis and optical imaging andmanipulation of neural activity. W found that neural coding for discrimination of multipletemperatures signaling through glutamate neurotransmission, molecular mechanism fordiscrimination of sensations, and localization mechanisms of synapses involved ininformation discrimination in axon.
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