Novel screening method for drugs using chlorophyll fluorescence
| Project/Area Number |
23657041
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Waseda University |
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Principal Investigator |
SONOIKE Kintake 早稲田大学, 教育・総合科学学術院, 教授 (30226716)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | クロロフィル蛍光 / 薬剤スクリーニング / シアノバクテリア / 代謝 / 光合成 / 呼吸 / NDH複合体 / 末端酸化酵素 / 阻害剤 / シアン化カリウム / 薬剤 / スクリーニング |
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| Research Abstract |
The aim of this study is to develop the novel method to screen drugs affecting specific metabolic process. We used chlorophyll fluorescence for that purpose, using cyanobacteria, unicellular photosynthetic organisms. The obtained results demonstrate that the addition of the several metabolite to cyanobacterial cells results in the specific change in the induction kinetics of the chlorophyll fluorescence.
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Report
(4 results)
Research Products
(24 results)
