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Development of a method for evaluation of ageing in cerebral neuronal circuit using circadian rhythm as a gauge

Research Project

Project/Area Number 23657056
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Animal physiology/Animal behavior
Research InstitutionOkayama University

Principal Investigator

TOMIOKA Kenji  岡山大学, 自然科学研究科, 教授 (30136163)

Co-Investigator(Kenkyū-buntansha) YOSHII Taishi  岡山大学, 大学院・自然科学研究科, 准教授 (50611357)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords概日リズム / 概日時計 / 時計ニューロン / 加齢 / 脳 / 老化 / ショジョウバエ / 神経回路 / ショウジョウバエ
Research Abstract

The goal of this study was to establish a method to evaluate ageing of cerebral neuronal circuits using overt circadian rhythms as a gauge in Drosophila. Behavioral and molecular analyses revealed that age dependent retardation of a neuropeptide, pigment-dispersing factor (PDF), expression in the dorsal terminal of PDF immunoreactive cerebral clock neurons correlated with the ageing of behavioral rhythms. Overexpression of the peptide strengthened not only the activity rhythm but also molecular oscillation of clock genes even in old flies. Thus measuring the behavioral rhythms may be sufficient to evaluate ageing of the underlying neuronal circuit.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 4 results) Presentation (15 results) (of which Invited: 2 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Sexual interactions influence the molecular oscillations in DN1 pacemaker neurons in Drosophila melanogaster2013

    • Author(s)
      Hanafusa S., Kawaguchi T., Umezaki Y., Tomioka K., Yoshii T
    • Journal Title

      PLoS ONE

      Volume: 8(12) Issue: 12 Pages: e84495-e84495

    • DOI

      10.1371/journal.pone.0084495

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pigment-dispersing factor is involved in age-dependent rhythm changes in Drosophila melanogaster2012

    • Author(s)
      Umezaki Y., Yoshii T., Kawaguchi T., Helfrich-Förster C., Tomioka K
    • Journal Title

      Journal of Biological Rhythms

      Volume: 27 Pages: 423-432

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pigment-dispersing factor is involved in age-dependent rhythm changes in Drosophila melanogaster.2012

    • Author(s)
      Umezaki, Yujiro
    • Journal Title

      Journal of Biological Rhythms

      Volume: 27 Issue: 6 Pages: 423-432

    • DOI

      10.1177/0748730412462206

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peripheral circadian rhythms and their regulatory mechanism in insects and some other arthropods : a review2012

    • Author(s)
      Tomioka, Kenji
    • Journal Title

      Journal of Comparative Physiology B

      Volume: 182 Issue: 6 Pages: 729-740

    • DOI

      10.1007/s00360-012-0651-1

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blocking synaptic transmission with tetanus toxin light chain reveals modes of neurotransmission in the PDF-positive circadian clock neurons of Drosophila melanogaster2011

    • Author(s)
      Umezaki Y., Yasuyama K., Nakagoshi H., Tomioka K
    • Journal Title

      Journal of Insect Physiology

      Volume: 57(9) Pages: 1290-1299

    • Related Report
      2013 Final Research Report
  • [Journal Article] Temperature entrainment of the circadian cuticle deposition rhythm in Drosophila melanogaster2011

    • Author(s)
      Ito C., Goto S.G., Tomioka K., Numata H
    • Journal Title

      Journal of Biological Rhythms

      Volume: 26 Pages: 14-23

    • NAID

      120004185009

    • Related Report
      2013 Final Research Report
  • [Journal Article] Blocking synaptic transmission with tetanus toxin light chain reveals modes of neurotransmission in the PDF-positive circadian clock neurons of Drosophila melanogaster2011

    • Author(s)
      Umezaki, Yujiro
    • Journal Title

      Journal of Insect Physiology

      Volume: 57(9) Issue: 9 Pages: 1290-99

    • DOI

      10.1016/j.jinsphys.2011.06.004

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ショウジョウバエ概日リズムを制御する時計ニューロンネットワーク2014

    • Author(s)
      富岡憲治
    • Organizer
      第2回視交叉上核アリーナ
    • Place of Presentation
      札幌市
    • Year and Date
      2014-01-23
    • Related Report
      2013 Final Research Report
  • [Presentation] キイロショウジョウバエ概日時計のCRY 依存的な光同調神経機構2013

    • Author(s)
      吉井大志, Christa Kistenpfennig, 富岡憲治
    • Organizer
      日本動物学会第84回大会
    • Year and Date
      2013-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 昆虫の概日時計機構に関する神経生物学的研究2013

    • Author(s)
      富岡憲治
    • Organizer
      平成25年度日本動物学会賞受賞者講演, 日本動物学会第84回大会
    • Place of Presentation
      岡山市
    • Year and Date
      2013-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] キイロショウジョウバエ雌雄ペア時の活動リズム変調機構2012

    • Author(s)
      花房志帆, 吉井大志, 富岡憲治
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪大学, 大阪市
    • Year and Date
      2012-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] キイロショウジョウバエ活動リズムの加齢変化へのPDF の関与2012

    • Author(s)
      梅 崎勇次郎, 川口知晃, 吉井大志, Helfrich-Foerster Charllotte, 富岡憲治
    • Organizer
      日本動物学会中国四国支部大会
    • Place of Presentation
      島根大学, 松江市
    • Year and Date
      2012-05-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Sexual interaction influences circadian activity pattern in Drosophila melanogaster2012

    • Author(s)
      Yoshii T., Hanafusa S., Umezaki Y., Tomioka K
    • Organizer
      SRBR 2012
    • Place of Presentation
      Sandestin Golf and Beach Resort, Destin, Florida
    • Related Report
      2013 Final Research Report
  • [Presentation] キイロショウジョウバエ活動リズムの加齢変化へのPDFの関与2012

    • Author(s)
      梅崎勇次郎
    • Organizer
      日本動物学会中国四国支部大会
    • Place of Presentation
      島根大学
    • Related Report
      2012 Research-status Report
  • [Presentation] キイロショウジョウバエ雌雄ペア時の活動リズム変調機構2012

    • Author(s)
      花房志帆
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪大学
    • Related Report
      2012 Research-status Report
  • [Presentation] キイロショウジョウバエ雌雄個体間相互作用による概日リズムの変調機構2011

    • Author(s)
      花房志帆, 富岡憲治
    • Organizer
      日本動物学会中四国支部大会
    • Place of Presentation
      香川大学, 高松市
    • Related Report
      2013 Final Research Report
  • [Presentation] 加齢による色素拡散因子(PDF)の発現レベル低下が概日リズムの加齢変調を引き起こす2011

    • Author(s)
      梅崎勇次郎, 吉井大志, Helfrich-Foerster C, 富岡憲治
    • Organizer
      第18回日本時間生物学会学術大会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Final Research Report
  • [Presentation] キイロショウジョウバエ雌雄個体間相互作用による概日リズムの変調機構2011

    • Author(s)
      花房志帆
    • Organizer
      日本動物学会中四国支部大会
    • Place of Presentation
      香川大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 加齢による色素拡散因子(PDF)の発現レベル低下が概日リズムの加齢変調を引き起こす2011

    • Author(s)
      梅崎勇次郎
    • Organizer
      第18回日本時間生物学会学術大会
    • Place of Presentation
      名古屋市
    • Related Report
      2011 Research-status Report
  • [Presentation] A possible synaptic transmission involved in the Drosophila circadian clock2011

    • Author(s)
      Tomioka, Kenji
    • Organizer
      3rd World Congress of Chronobiology(招待講演)
    • Place of Presentation
      Puebla, Mexico
    • Related Report
      2011 Research-status Report
  • [Presentation] ショウジョウバエ概日リズムを制御する時計ニューロンネットワーク

    • Author(s)
      富岡憲治
    • Organizer
      第2回視交叉上核アリーナ
    • Place of Presentation
      北海道大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 昆虫の概日時計機構に関する神経生物学的研究

    • Author(s)
      富岡憲治
    • Organizer
      平成25年度日本動物学会
    • Place of Presentation
      岡山大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] PartIII無脊椎動物の概日リズム 10章 生理機構, 時間生物学(海老原史樹史, 吉村崇編)2012

    • Author(s)
      富岡憲治, 松本顕
    • Publisher
      化学同人
    • Related Report
      2013 Final Research Report
  • [Book] 化学同人2012

    • Author(s)
      富岡憲治
    • Publisher
      海老原史樹史、吉村崇編、時間生物学、PartIII無脊椎動物の概日リズム 10章 生理機構
    • Related Report
      2012 Research-status Report
  • [Book] 化学同人2012

    • Author(s)
      富岡憲治
    • Publisher
      PartIII 無脊椎動物の概日リズム 10章 生理機構、「時間生物学」、海老原史樹史、吉村崇編
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.biol.okayama-u.ac.jp/tomioka1/top.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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