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Search of receptor for a novel neuropeptide in the hypothalamus

Research Project

Project/Area Number 23657057
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Animal physiology/Animal behavior
Research InstitutionHiroshima University

Principal Investigator

UKENA Kazuyoshi  広島大学, 大学院・総合科学研究科, 准教授 (10304370)

Co-Investigator(Kenkyū-buntansha) SAITO Yumiko  広島大学, 大学院・総合科学研究科, 教授 (00215568)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords受容体 / 神経ペプチド / カルシウムイメージング / 培養細胞 / 内因性リガンド
Research Abstract

Recently, we identified a novel hypothalamic gene in the avian and mammalian brains. We predict that this novel gene encodes a neuropeptide and this peptide is involved in the energy homeostasis. The identification of the specific receptor is essential to elucidate the physiological roles of the neuropeptide. In this study, we soughtthe receptor for the neuropeptide by signal transduction assay . Unfortunately , we could not find the specific receptor in this study .

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (41 results)

All 2013 2012 2011 Other

All Journal Article (25 results) (of which Peer Reviewed: 20 results) Presentation (13 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Identification, localization and function of a novel neuropeptide, 26RFa, and its cognate receptor, GPR103, in the avian hypothalamus.2013

    • Author(s)
      Ukena K, Tachibana T, Tobari Y, Leprince J, Vaudry H, Tsutsui K.
    • Journal Title

      Gen. Comp. Endocrinol.

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 12013

    • Author(s)
      Nagata A, Hamamoto A, Horikawa M, Yoshimura K, Takeda S, Saito Y
    • Journal Title

      Gen. Comp.Endocrinol

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interrelation between melanocyte-stimulating hormone and melanin-concentrating hormone in physiological body color change: roles emerging from barfin flounder Verasper moseri.2013

    • Author(s)
      Mizusawa K, Kobayashi Y, Yamanome T, Saito Y, Takahashi A
    • Journal Title

      Gen. Comp.Endocrinol

      Volume: 181 Pages: 229-234

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review: Identification, localization and function of a novel neuropeptide, 26RFa, and its cognate receptor, GPR103 in the avian hypothalamus2013

    • Author(s)
      K. Ukena, T. Tachibana, Y. Tobari, J. Leprince, H. Vaudry, K. Tsutsui
    • Journal Title

      Gen. Comp. Endocrinol.

      Volume: 190 Pages: 42-46

    • DOI

      10.1016/j.ygcen.2013.03.014

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 12013

    • Author(s)
      Nagata A, Hamamoto A, Horikawa M, Yoshimura K, Takeda S, Saito Y
    • Journal Title

      General and Comparative Endocrinology

      Volume: 188 Issue: 1 Pages: 159

    • DOI

      10.1016/j.ygcen.2013.02.020

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification, expression, and physiological functions of siberian hamster gonadotropin-inhibitory hormone2012

    • Author(s)
      Ubuka T, Inoue K, Fukuda Y, Mizuno T, Ukena K, Kriegsfeld LJ, Tsutsui K
    • Journal Title

      Endocrinology

      Volume: 153 Pages: 373-385

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation of Phe318 within the NPxxY(x)5,6F motif in melanin-concentrating hormone receptor 1 results in an efficient signaling activity.2012

    • Author(s)
      Hamamoto A, Horikawa M, Saho T, Saito Y.
    • Journal Title

      Front. Endocrinology

      Volume: 3.147 Pages: 1-10

    • DOI

      10.3389/fendo.2012.00147

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Melanocortinsystemsonpigmentdispersioninfishchromatophores2012

    • Author(s)
      小林勇喜
    • Journal Title

      frontiers in ENDOCINOLOGY

      Volume: 3-9 Pages: 1-6

    • DOI

      10.3389/fendo.2012.00009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] オーファン GPCR 系とうつ病2012

    • Author(s)
      斎藤祐見子
    • Journal Title

      日本薬理学会編集「実践治療薬」金芳堂

      Pages: 273-280

    • Related Report
      2012 Final Research Report
  • [Journal Article] Identification, expression, and physiological functions of Siberian hamster gonadotropin-inhibitory hormone2012

    • Author(s)
      T.Ubuka, K.Tsutsui, et al
    • Journal Title

      Endocrinology

      Volume: 153 Issue: 1 Pages: 373-385

    • DOI

      10.1210/en.2011-1110

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] MCH 「摂食制御の分子過程」2011

    • Author(s)
      長崎弘、斎藤祐見子
    • Journal Title

      生体の科学

      Volume: 62 Pages: 37-43

    • Related Report
      2012 Final Research Report
  • [Journal Article] 日本における生理活性ペプチド研究の流れとその展開2011

    • Author(s)
      児島将康、斎藤祐見子
    • Journal Title

      実験医学増刊号「代謝・内分泌ネットワークと医薬応用」

      Volume: 29 Pages: 14-22

    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Journal Article] MCH の最新の話題2011

    • Author(s)
      斎藤祐見子
    • Journal Title

      実験医学増刊号「代謝・内分泌ネットワークと医薬応用」

      Volume: 29 Pages: 54-59

    • Related Report
      2012 Final Research Report
  • [Journal Article] 新規生理活性ペプチドの探索方法の進歩2011

    • Author(s)
      斎藤祐見子、児島将康
    • Journal Title

      実験医学増刊号「代謝・内分泌ネットワークと医薬応用」

      Volume: 29 Pages: 80-85

    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Journal Article] Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates.2011

    • Author(s)
      Ukena K, Vaudry H, Leprince J, Tsutsui K
    • Journal Title

      Cell Tissue Res

      Volume: 343 Pages: 475-481

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-2 family isolated from the skin of the endangered frog Odorrana ishikawae.2011

    • Author(s)
      Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K
    • Journal Title

      Peptides

      Volume: 32 Pages: 2052-2057

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning.2011

    • Author(s)
      Iwakoshi-Ukena E, Soga M, Okada G, Fujii T, Sumida M, Ukena K
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 412 Pages: 673-677

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae.2011

    • Author(s)
      Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M
    • Journal Title

      Peptides

      Volume: 32 Pages: 670-676

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synchronised expressions of LPXRFamide peptide and its receptor genes: seasonal, diurnal and circadian changes during spawning period in grass puffer.2011

    • Author(s)
      Shahjahan Md, Ikegami T, Osugi T, Ukena K, DOI: H, Hattori A, Tsutsui K, Ando H.
    • Journal Title

      J. Neuroendocrinol.

      Volume: 23 Pages: 39-51

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification, localisation and functional implication of 26RFa orthologue peptide in the brain of zebra finch (Taeniopygia guttata)2011

    • Author(s)
      Tobari Y, Iijima N, Tsunekawa K, Osugi T, Haraguchi S, Ubuka T, Ukena K, Okanoya K, Tsutsui K, Ozawa H.
    • Journal Title

      J. Neuroendocrinol

      Volume: 23 Pages: 791-803

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis, mode of action and functional significance of neurosteroids in the Purkinje cell2011

    • Author(s)
      Kazuyoshi Tsutsui
    • Journal Title

      Frontiers in Endocrinology

      Volume: 2 Pages: 1-9

    • DOI

      10.3389/fendo.2011.00061

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2.2011

    • Author(s)
      Hamamoto A, Mizusawa K, Takahashi A, Saito Y.
    • Journal Title

      Regul.Pept.

      Volume: 169 Pages: 6-12

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibiting roles of melanin-concentrating hormone for skin pigment dispersion in barfin flounder, Verasper moseri2011

    • Author(s)
      Mizusawa K, Kobayashi Y, Sunuma T, Asahida T, Saito Y, Takahashi A
    • Journal Title

      Gen.Comp. Endocrinol

      Volume: 171 Pages: 75-81

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning2011

    • Author(s)
      Iwakoshi-Ukena E
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 412 Issue: 4 Pages: 673-677

    • DOI

      10.1016/j.bbrc.2011.08.023

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification, Localisation and Functional Implication of 26RFa Orthologue Peptide in the Brain of Zebra Finch (Taeniopygia guttata)2011

    • Author(s)
      Y.Tobari, K.Tsutsui, et al
    • Journal Title

      J.Neuroendocrinol.

      Volume: 23 Issue: 9 Pages: 791

    • DOI

      10.1111/j.1365-2826.2011.02179.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ラットの視床下部新規神経ペプチドの形態学的解析-既知の生理活性物質との相関と絶食処理に伴う変化-2012

    • Author(s)
      前嶋 翔、岩越栄子、佐藤慧太、坂本浩隆、坂本竜哉、浮穴和義
    • Organizer
      第37回日本比較内分泌学会大会
    • Place of Presentation
      福井
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] ラットの視床下部新規遺伝子がコードしている神経ペプチドの摂食行動への影響2012

    • Author(s)
      鹿野健史朗、近藤邦裕、谷内秀輔、大口悦宏、大山晴香、益田恵子、前嶋 翔、岩越栄子、浮穴和義
    • Organizer
      第37回日本比較内分泌学会大会
    • Place of Presentation
      福井
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 鳥類の視床下部で発見した新規神経ペプチド前駆体遺伝子の機能解析-摂食調節に着目して-2012

    • Author(s)
      浮穴和義、谷内秀輔、前嶋翔、古満芽久美、大山晴香、岩越栄子
    • Organizer
      第46回日本味と匂学会 シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2012-10-04
    • Related Report
      2012 Final Research Report
  • [Presentation] ラットの視床下部新規遺伝子がコードしている神経ペプチドの形態学的解析2012

    • Author(s)
      前嶋 翔、佐藤真実、岩越-浮穴栄子、浮穴和義
    • Organizer
      第83回日本動物学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2012-09-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規摂食調節関連遺伝子がコードする神経ペプチドのラット視床下部における形態学的解析2012

    • Author(s)
      前嶋 翔、岩越-浮穴栄子、浮穴和義
    • Organizer
      第17回日本行動神経内分泌研究会
    • Place of Presentation
      京都
    • Year and Date
      2012-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 鳥類ニワトリの視床下部で発見した新規神経ペプチドの前駆体遺伝子の解析2012

    • Author(s)
      浮穴和義、岩越-浮穴栄子、谷内秀輔、古満芽久美、橘 哲也
    • Organizer
      第64回日本動物学会中国四国支部大会
    • Place of Presentation
      島根
    • Year and Date
      2012-05-13
    • Related Report
      2012 Final Research Report
  • [Presentation] ラットの新規摂食調節関連遺伝子がコードしている神経ペプチドの摂食行動とエネルギー代謝への影響2012

    • Author(s)
      大口悦宏、谷内秀輔、古満芽久美、大山晴香、佐藤真実、益田恵子、岩越栄子、浮穴和義
    • Organizer
      2012 年度日本動物学会中国四国支部広島県例会
    • Place of Presentation
      広島
    • Year and Date
      2012-03-03
    • Related Report
      2012 Final Research Report
  • [Presentation] ニワトリの新規摂食調節関連遺伝子がコードしている神経ペプチドの摂食行動に及ぼす影響2012

    • Author(s)
      岩越栄子、橘 哲也、古満芽久美、浮穴和義
    • Organizer
      2012 年度日本動物学会中国四国支部広島県例会
    • Place of Presentation
      広島
    • Year and Date
      2012-03-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 鳥類の視床下部漏斗部で発見した新規遺伝子の機能解析-摂食調節機構に着目して-2011

    • Author(s)
      浮穴和義、岩越栄子
    • Organizer
      第38回日本神経内分泌学会学術集会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] マウスの視床下部における新規摂食調節関連遺伝子の解析2011

    • Author(s)
      佐藤真実、岩越-浮穴栄子、浮穴和義
    • Organizer
      第82回日本動物学会大会
    • Place of Presentation
      旭川
    • Year and Date
      2011-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 脊椎動物の視床下部に存在する新しい食欲調節ペプチドの発見と機能解析2011

    • Author(s)
      浮穴和義、岩越-浮穴栄子、大口悦宏、古満芽久美、佐藤真実、益田恵子、斎藤祐見子
    • Organizer
      平成 23 年度中国四国動物生理シンポジウム
    • Place of Presentation
      山口
    • Year and Date
      2011-09-03
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス視床下部における摂食調節に関わる新規遺伝子の mRNA 発現解析2011

    • Author(s)
      佐藤真実、岩越-浮穴栄子、浮穴和義
    • Organizer
      第63回日本動物学会中国四国支部大会
    • Place of Presentation
      香川
    • Year and Date
      2011-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 鳥類の視床下部漏斗部で発見した新規遺伝子の機能解析―摂食調節機構に着目して―2011

    • Author(s)
      浮穴和義
    • Organizer
      第38回日本神経内分泌学会学術集会(招待講演)
    • Place of Presentation
      東京都
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/ukena/

    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] ポリペプチド、ポリペプチドの製造方法、摂食調節組成物および摂食量の調節方法2011

    • Inventor(s)
      浮穴和義、岩越栄子、益田恵子、古満芽久美
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      2011-248006
    • Filing Date
      2011-11-11
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] ポリペプチド、ポリペプチドの製造方法、摂食調節組成物および摂食量の調節方法2011

    • Inventor(s)
      浮穴和義
    • Industrial Property Rights Holder
      浮穴和義
    • Industrial Property Number
      2011-248006
    • Filing Date
      2011
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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