Development of a methodology for the selective stimulation of new born granule cells in mammalian hippocampus
| Project/Area Number |
23657058
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Hiroshima University |
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Principal Investigator |
FURUKAWA Yasuo 広島大学, 大学院・総合科学研究科, 教授 (40209169)
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| Co-Investigator(Kenkyū-buntansha) |
MUKUDA Takao 広島大学, 大学院・総合科学研究科, 助教 (60346335)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ペプチド作動性イオンチャネル / FMRFamide / 海馬 / ペプチド作動性チャネル / 神経新生 / イオンチャネル |
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| Research Abstract |
By using an invertebrate peptide-gated Na+channel (FaNaC), we tried to establish a methodology to stimulate new neurons in the dentate gyrus of hippocampus. Several mutant channels of FaNaC were made, and two of them were found to be more sensitive to FMRFamide and show less desensitization compared to the wild-type channel. We are now trying to express these mutant channels in the dentate granule neurons.
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Report
(3 results)
Research Products
(20 results)
