| Project/Area Number |
23657076
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Structural biochemistry
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| Research Institution | University of Miyazaki (2012)
Osaka University (2011) |
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Principal Investigator |
WADA Kei 宮崎大学, テニュアトラック推進機構, 助教 (80379304)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUYAMA Keiichi 大阪大学, 大学院・理学研究科, 教授 (80032283)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 分子認識および相互作用 / ウイルス / 赤潮 / 特異的認識 / 構造 / X線結晶構造解析 |
|---|
| Research Abstract |
Heterosigma akashiwo virus (HaV) is a large virus specifically infecting the harmful bloom-forming flagellate Heterosigma akashiwo. Based on field surveys and cross-reactivity tests between the host clones and HaV clones, suggesting that this strain-dependent infection may play an important role in determining the clonal composition and maintaining the intraspecies diversity of natural H. akashiwo populations. In this study, to elucidate the mechanism of the specific host infection, the Vp183 protein, the specific host recognition protein, was overproduced.
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