Structural analysis of mitochondrial apoptotic pore
| Project/Area Number |
23657084
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SHIMIZU Shigeomi 東京医科歯科大学, 難治疾患研究所, 教授 (70271020)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞情報伝達機構 / アポトーシス / ネクローシス / ミトコンドリア / Bax / Bak / 電子顕微鏡 / 生体膜 |
|---|
| Research Abstract |
The molecular mechanism of apoptotic mitochondrial permeability increase has not been fully elucidated yet. We aimed to analyze this structure using electron and fluorescence microscopes. In this research, we found the occurrence of criste fusion and opening, outer membrane blebbing, and Bak oligomerization during apoptosis. These findings unveil structural mechanism of apoptotic mitochondrial changes.
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Report
(3 results)
Research Products
(54 results)
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[Journal Article] Shigella targets epithelial tricellular junctions to spread between cells via a noncanonicalclathrin-dependent endocytic pathway2012
Author(s)
M. Fukamatsu, M. Ogawa, S. Arakawa, H.Ashida, M. Suzuki, M. Furuse, K. Nakayama, S. Shimizu, M. Kin, H. Mimuro, C. Sasakawa
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Journal Title
Cell Host Microbe
Volume: 11
Pages: 325-336
Related Report
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[Journal Article] Stress-activated protein kinase MKK7 regulates axon elongation in thedeveloping cerebral cortex2011
Author(s)
T. Yamasaki, H. Kawasaki, S. Arakawa, K. Shimizu, S. Shimizu, O. Reiner, H. Okano, S. Nishina, N. Azuma, J.M. Penninger, T. Katada, H Nishina
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Journal Title
Journal ofNeuroscience
Volume: 31
Pages: 16872-16883
Related Report
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[Journal Article] Spatialcoupling of mTOR and autophagy augments secretory phenotypes2011
Author(s)
M. Narita, A.R.J. Young, S. Arakawa, S.A. Samarajiwa, T. Nakashima, S. Yoshida, S.K. Hong, L.S. Berry, S. Reichelt, M. Ferreira, S. Tavare, K. Inoki, S. Shimizu, M. Narita
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Journal Title
Science
Volume: 332
Pages: 966-970
Related Report
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[Journal Article] Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/Bax-deficient mice2011
Author(s)
H. Hikita, T. Takehara, T. Kodama, S. Shimizu, M. Shigekawa, A. Hosui, T. Miyagi, T. Tatsumi, H. Ishida, Li W, T. Kanto, N. Hiramatsu, S. Shimizu, Y. Tsujimoto, N. Hayashi
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Journal Title
Hepatology
Volume: 54
Pages: 240-251
Related Report
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[Journal Article] Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.2011
Author(s)
Yamasaki T, Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T, Nishina H.
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Journal Title
Journal of Neuroscience
Volume: 31
Pages: 16872-16883
Related Report
Peer Reviewed
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