| Project/Area Number |
23657090
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
OKAMOTO Koji 大阪大学, 大学院・生命機能研究科, 特任准教授 (40455217)
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| Research Collaborator |
OKAMOTO Noriko 大阪大学, 大学院・生命機能研究科, 特任研究員 (90568750)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | ミトコンドリア / オートファジー / 品質管理 / オルガネラ膜動態 / 出芽酵母 |
|---|
| Research Abstract |
In this study, we focused on mitophagy, one of the mitochondrial quality control systems that selectively degrades the energy-converting organelles governing cell life and death via autophagy. Particularly, using budding yeast as a model organism, we sought to establish the molecular bases and regulatory tools that artificially suppress or facilitate mitophagy.
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