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Molecular analysis of sex difference in the hippocampus, a center for learning and memory

Research Project

Project/Area Number 23657098
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biophysics
Research InstitutionThe University of Tokyo

Principal Investigator

KAWATO Suguru  東京大学, 総合文化研究科, 教授 (50169736)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords海馬の性差 / 神経ステロイド / 脳ステロイドの性差 / 記憶の性差 / シナプスの性差 / 性差 / スパインの性差 / 海馬 / 雌雄差 / 記憶
Research Abstract

The goal of the current study is elucidation of sex difference in the hippocampus, a center for learning and memory. (1) Concentration of sex hormones in the hippocampus exhibited clear sex difference. Hippocampal concentration of estradiol (E2), the most potent estrogen, was higher in male than that in female. Hippocampal E2 fluctuated across the estrous cycle. The concentration of hippocampal testosterone (T) was higher in male than female, which did not fluctuate. (2) Surprisingly, the expression level of the steroidogenic enzymes and receptors in the hippocampus exhibited neither sex difference nor fluctuation across the estrous cycle.(3) The density of dendritic spines in female hippocampus fluctuated across the estrous cycle. The total spine density showed the maximum at Pro and D1, and the minimum at Est and D2 whereas the total spine density in male was as high as that in female at Pro or D1. The fluctuating pattern of spine density corresponded to that of hippocampal concentration of sex steroids. Taken together, there is clear sex difference in the hippocampus-synthesized sex hormones which play a crucial role in regulating the density of dendritic spines

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (51 results)

All 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (32 results) (of which Invited: 1 results) Remarks (2 results)

  • [Journal Article] Bisphenol A significantly modulates long-term depression in the hippocampus as observed by multielectrode system.2013

    • Author(s)
      Hasegawa Y, Ogiue-Ikeda M, Tanabe N,Kimoto T, Hojo Y, Yamazaki T, Kawato S.
    • Journal Title

      Neuroendocrinol. Lett.

      Volume: 34(2) Pages: 129-34

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] De novo synthesized estradiol protects against methylmercury-induced neurotoxicity in cultured rat hippocampal slices.2013

    • Author(s)
      Takeshi Yamazaki
    • Journal Title

      PLoS One.

      Volume: 8(2): Issue: 2 Pages: e55559-e55559

    • DOI

      10.1371/journal.pone.0055559

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis.2012

    • Author(s)
      Okamoto M, Hojo Y, Inoue K, Matsui T, Kawato S, Mc Ewen BS, Soya H.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109 Issue: 32 Pages: 13100-13105

    • DOI

      10.1073/pnas.1210023109

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Corticosterone Induces Rapid Spinogenesis via Synaptic Glucocorticoid Receptors and Kinase Networks in Hippocampus.2012

    • Author(s)
      Komatsuzaki Y, Hatanaka Y, Murakami G, Mukai H, Hojo Y, Saito M, Kimoto T, Kawato S.
    • Journal Title

      PLoS ONE

      Volume: 7(4) Issue: 4 Pages: e34124-e34124

    • DOI

      10.1371/journal.pone.0034124

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nanomolar dose of bisphenol A rapidly modulates spinogenesis in adult hippocampal neurons2012

    • Author(s)
      Tanabe N, Yoshino H, Kimoto T, Hojo Y, Ogiue-Ikeda M, Shimohigashi Y, Kawato S
    • Journal Title

      Mol Cell Endocrinol

      Volume: 351 Issue: 2 Pages: 317-325

    • DOI

      10.1016/j.mce.2012.01.008

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Corticosterone Induces Rapid Spinogenesis via Synaptic Glucocorticoid Receptors and Kinase Networks in Hippocampus.2012

    • Author(s)
      Komatsuzaki Y, Hatanaka Y, Murakami G, Mukai H, Hojo Y, Saito M, Kimoto T, Kawato S
    • Journal Title

      PLoS ONE

      Volume: 7(4)

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hippocampal synthesis of sex steroids and corticosteroids : essential for modulation of synaptic plasticity2011

    • Author(s)
      Hojo Y, Higo S, Kawato S, Hatanaka Y, Ooishi Y, Murakami G, Ishii H, Komatsuzaki Y, Ogiue-Ikeda M, Mukai H, Kimoto T
    • Journal Title

      Front Neuroendocrine Science

      Volume: 2 Pages: 43-43

    • DOI

      10.3389/fendo.2011.00043

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of synaptic plasticity by hippocampus synthesised estradiol2011

    • Author(s)
      Barron A, Hojo Y, Muka H, Higo S, Ooishi Y, Hatanaka Y, Ogiue-Ikeda M, Murakami G, Kimoto T, Kawato S
    • Journal Title

      Horm Mol Biol Clin Invest

      Volume: 7(2) Issue: 2 Pages: 361-375

    • DOI

      10.1515/hmbci.2011.118

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of synaptic plasticity in the hippocampus by hippocampus-derived estrogen and androgen2011

    • Author(s)
      Ooishi Y, Kawato S, Hojo Y, Hatanaka Y, Higo S, Murakami G, Komatsuzaki Y, Ogiue-Ikeda M, Kimoto T, Mukai H
    • Journal Title

      J steroid Biochem Mol Biol

      Volume: (In Press) Issue: 1-2 Pages: 37-51

    • DOI

      10.1016/j.jsbmb.2011.10.004

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous Synthesis of Corticosteroids in the Hippocampus2011

    • Author(s)
      Higo S, Hojo Y, Ishii H, Komatsuzaki Y, Ooishi Y, Murakami G, Mukai H, Yamazaki T, Nakahara D, Anna B, Kimoto T, Kawato S
    • Journal Title

      PLoS ONE

      Volume: 6(7) Issue: 7 Pages: 21631-21631

    • DOI

      10.1371/journal.pone.0021631

    • NAID

      120005300503

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estradiol Rapidly Rescues Synaptic Transmission from Corticosterone-induced Suppression via Synaptic/Extranuclear steroid Receptors in the Hippocampus2011

    • Author(s)
      Ooishi Y, Mukai H, Hojo Y, Murakami G, Hasegawa Y, Shindo T, Morrison JH, Kimoto T, Kawato S
    • Journal Title

      Cereb Cortex

      Volume: 22(4) Issue: 4 Pages: 926-936

    • DOI

      10.1093/cercor/bhr164

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Automated analysis of spines from confocal laser microscopy images : application to the discrimination of androgen and estrogen effects on spinogenesis2011

    • Author(s)
      Mukai H, Hatanaka Y, Mitsuhashi K, Hojo Y, Komatsuzaki Y, Sato R, Murakami G, Kimoto T, Kawato S
    • Journal Title

      Cereb Cortex

      Volume: 21(12) Issue: 12 Pages: 2704-2711

    • DOI

      10.1093/cercor/bhr059

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Saito MThe binding site for acute corticosterone effects on N-methyl-D-aspartate receptor-mediated Ca2+ signals in mouse hippocampal slices.J.2011

    • Author(s)
      Osanai H, Suzuki A, Komatsuzaki Y, Mukai H, Kawato S
    • Journal Title

      Biophys. Chem.

      Volume: 2 Issue: 04 Pages: 430-433

    • DOI

      10.4236/jbpc.2011.24050

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estradiol Rapidly Rescues Synaptic Transmission from Corticosterone-induced Suppression via Synaptic/Extranuclear Steroid Receptors in the Hippocampus.2011

    • Author(s)
      Ooishi Y, Mukai H, Hojo Y, Murakami G, Hasegawa Y, Shindo T, Morrison JH, Kimoto T, Kawato S
    • Journal Title

      Cereb Cortex

      Volume: 22 Pages: 926-936

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Automated analysis of spines from confocal laser microscopy images: application to the discrimination of androgen and estrogen effects on spinogenesis.2011

    • Author(s)
      Mukai H, Hatanaka Y, Mitsuhashi K, Hojo Y, Komatsuzaki Y, Sato R, Murakami G, Kimoto T, Kawato S
    • Journal Title

      Cereb Cortex

      Volume: 21 Pages: 2704-2711

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hippocampal synthesis of sex steroids and corticosteroids: essential for modulation of synaptic plasticity.2011

    • Author(s)
      Hojo Y, Higo S, Kawato S, Hatanaka Y, Ooishi Y, Murakami G, Ishii H, Komatsuzaki Y, Ogiue-Ikeda M, Mukai H, Kimoto T
    • Journal Title

      Front Neuroendocrine Science

      Volume: 2

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endogenous Synthesis of Corticosteroids in the Hippocampus.2011

    • Author(s)
      Higo S, Hojo Y, Ishii H, Komatsuzaki Y, Ooishi Y, Murakami G, Mukai H, Yamazaki T, Nakahara D, Anna B, Kimoto T, Kawato S
    • Journal Title

      PLoS ONE

      Volume: 6

    • NAID

      120005300503

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ビスフェノールAの周生期曝露は成獣雄雌の海馬神経シナプスを変動させる2012

    • Author(s)
      李香蓮,芳野日南子,木本哲也,粟生修司,川戸佳
    • Organizer
      日本内分泌撹乱化学物質学会第15回研究発表会
    • Place of Presentation
      東京大学山上会館(東京都、文京区)
    • Year and Date
      2012-12-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 海馬での年齢依存的な性ホルモン受容体・合成酵素遺伝子の発現変動解析2012

    • Author(s)
      木本哲也,若林正彦,川戸佳
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学東山キャンパス(愛知県、名古屋市)
    • Year and Date
      2012-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 海馬でのアクチビンによるシナプス可塑性の急性制御2012

    • Author(s)
      長谷川賢卓,向井秀夫,浅島誠,大石悠貴,川戸佳
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学東山キャンパス(愛知県、名古屋市)
    • Year and Date
      2012-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 記憶・学習中枢海馬の性差は海馬で合成されるホルモンによるものである2012

    • Author(s)
      北條泰嗣,若林正彦,吉田広太郎,木本哲也,川戸佳
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学東山キャンパス(愛知県、名古屋市)
    • Year and Date
      2012-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] コルチコステロンは、シナプス局在のGR-kinase系を介して、海馬神経シナプスを増やす2012

    • Author(s)
      小松崎良将,粕谷昌寿,北條泰嗣,川戸佳
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学東山キャンパス(愛知県、名古屋市)
    • Year and Date
      2012-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規なスパイン解析プログラム2012

    • Author(s)
      向井秀夫,畑中悠佑,三橋賢司,村上元,北條泰嗣,川戸佳
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学東山キャンパス(愛知県、名古屋市)
    • Year and Date
      2012-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 老化に伴う海馬神経シナプスの密度の減少と記憶の劣化2012

    • Author(s)
      川戸佳,李香蓮,北條泰嗣
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学東山キャンパス(愛知県、名古屋市)
    • Year and Date
      2012-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] コルチコステロンは急性的に海馬のスパイン新生を引き起こす2012

    • Author(s)
      小松崎良将,北條泰嗣,畑中悠佑,向井秀夫,村上元,川戸佳
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Acute modulation of synaptic plasticityofpyramidal neurons by activin in adult hippocampus2012

    • Author(s)
      Hasegawa Y, Mukai H, Asashima M, OoishiY, Kawato S
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 老化による脳の性ステロイドの減少が海馬神経シナプスを減少させる2012

    • Author(s)
      川戸佳
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 音楽のテンポが人の内分泌系に及ぼす効果2012

    • Author(s)
      大石悠貴,向井秀夫,渡辺謙,川戸佳
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット海馬シナプスにおけるステロイドの合成とその作用2012

    • Author(s)
      北條泰嗣,向井秀夫,若林正彦,吉田広太郎,山崎岳,木本哲也,川戸佳
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 海馬の神経シナプスを制御する性ステロイド合成と受容体に性差はあるか2012

    • Author(s)
      若林正彦,北條泰嗣,肥後心平,川戸佳
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Hippocampus-synthesized estrogen and androgen rapidly modulate LTP and dendritic spines2012

    • Author(s)
      S. KAWATO, Y. HOJO, Y. OOISHI, S.HIGO, H. MUKAI
    • Organizer
      Society for Neuroscienece, Annual Meeting
    • Place of Presentation
      New Orleans USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Hippocampus-synthesized estrogen and androgen rapidly modulate LTP and dendritic spines2012

    • Author(s)
      S. KAWATO, Y. HOJO, H. MUKAI, Y. OOISHI
    • Organizer
      Soceaty for Neuroscience
    • Place of Presentation
      New Olreans USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mathematical and automated analysis of dendritic spines from confocal laser microscopy images2012

    • Author(s)
      H. MUKAI,, S. KAWATO
    • Organizer
      Soceaty for Neuroscience
    • Place of Presentation
      New Olreans USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] ビスフェノールAの周生期曝露は成獣雄雌の海馬神経シナプスを変動させる2011

    • Author(s)
      若林正彦,芳野日南子,木本哲也,粟生修司,川戸佳
    • Organizer
      第14回日本内分泌撹乱化学物質学会第14回研究発表会
    • Place of Presentation
      東京大学山上会館(東京都、文京区)
    • Year and Date
      2011-12-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 記憶・学習中枢海馬が合成する男性・女性ホルモンとその作用2011

    • Author(s)
      北條泰嗣,川戸佳
    • Organizer
      第82回日本動物学会大会
    • Place of Presentation
      旭川市大雪クリスタルホール(北海道、旭川市)
    • Year and Date
      2011-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 記憶・学習中枢海馬に性差はあるか?その32011

    • Author(s)
      北條泰嗣,肥後心平,上林正修,向井秀夫,木本哲也,川戸佳
    • Organizer
      第49回日本生物物理学会年会
    • Place of Presentation
      兵庫県立大学(兵庫県、姫路市)
    • Year and Date
      2011-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 老化に伴う海馬神経シナプスの密度の減少2011

    • Author(s)
      芳野日南子,北條泰嗣,鍋嶋美貴,川戸佳
    • Organizer
      第49回日本生物物理学会年会
    • Place of Presentation
      兵庫県立大学(兵庫県、姫路市)
    • Year and Date
      2011-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] シナプス小胞分極におけるミトコンドリアの役割2011

    • Author(s)
      小野島匠,手崎碧,菊池歩,川戸佳,太田善浩
    • Organizer
      第49回日本生物物理学会年会
    • Place of Presentation
      兵庫県立大学(兵庫県、姫路市)
    • Year and Date
      2011-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] オスは脳海馬で合成する女性ホルモンにより記憶力を高める2011

    • Author(s)
      長谷川賢卓,川戸佳
    • Organizer
      第49回日本生物物理学会年会
    • Place of Presentation
      兵庫県立大学(兵庫県、姫路市)
    • Year and Date
      2011-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Sex hormone synthesis and synaptocrinology in rat hippocampal synapses2011

    • Author(s)
      Hojo Y, Higo S, Mukai H, Harada N, Yamazaki T, Kimoto T, Kawato S
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2011-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Sex differences in the steroidogenic systems in the rat hippocampus2011

    • Author(s)
      Uebayashi M, Higo S, Hojo Y, Kominami T, Kawato S
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2011-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Automated analysis of spines from confocal laser microscopy images: application to the discrimination of androgen and estrogeneffects on hippocampal neurons2011

    • Author(s)
      Mukai H, Hatanaka Y, Mitsuhashi K, Hojo Y, Kawato S
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2011-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Corticosterone induced rapid spinogenesis via synaptic glucocorticoid receptor and kinases in rat hippocampus2011

    • Author(s)
      Komatsuzaki Y, Hojo Y, Hatanaka Y, Murakami G, Mukai H, Kawato S
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2011-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel automatic analysis of the enhance effect by estrogen and androgen on the hippocampus spines2011

    • Author(s)
      Kawato S
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2011-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Hippocampus-synthesized estrogen and androgen rapidly modulate LTP and dendritic spines2011

    • Author(s)
      S. KAWATO, Y. HOJO, Y. OOISHI, S. HIGO, H. MUKAI
    • Organizer
      Society for Neuroscienece, Annual Meeting
    • Place of Presentation
      Washington USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 記憶・学習中枢海馬に性差はあるか?その32011

    • Author(s)
      北條泰嗣, 肥後心平, 上林正修, 向井秀夫, 木本哲也, 川戸佳
    • Organizer
      第34回 日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] ラット海馬シナプスにおけるステロイドの合成とその作用

    • Author(s)
      川戸佳、北條泰嗣
    • Organizer
      神経科学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 海馬で合成される神経ステロイドの抗老化作用

    • Author(s)
      川戸佳
    • Organizer
      神経科学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 記憶・学習中枢海馬の性差は海馬で合成されるホルモンによるものである

    • Author(s)
      北条泰嗣、川戸佳
    • Organizer
      生物物理学会
    • Place of Presentation
      名古屋大学
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://glia.c.u-tokyo.ac.jp

    • Related Report
      2012 Final Research Report
  • [Remarks] 東京大学川戸研究室

    • URL

      http://glia.c.u-tokyo.ac.jp/index-j.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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