| Project/Area Number |
23657105
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IHARA Hideshi 大阪府立大学, 大学院・理学系研究科, 准教授 (60254447)
OKAJIMA Koji 大阪府立大学, 大学院・理学系研究科, 特認助教 (20438245)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | フォトトロピン / LOV ドメイン / MAP キナーゼ / キナーゼ活性光制御 / 青色光受容体 / LOVドメイン / MAPキナーゼ / ERK / 細胞分裂 / 分化光制御 / LOV2ドメイン / 細胞機能光制御 / MEK |
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| Research Abstract |
Phototropin is a blue light sensor in plant which mediates phototropic response et al., and act as a blue light regulated protein kinase. Using the photoactivation mechanism of kinase in the phototropin, we aim to produce a new animal cell of which physiological responses, cell division and cell differentiation, can be switchable by light illumination through controlling the kinase activity of the key protein kinase involved. We introduced the in vitro analysis system in which the regulation of the key enzyme activity can be studied.
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