Development of Scanning Optical Resonance Cavity RamanMicroscope and its Application to the Monitoring the Response of Cell under Mechanical Stimuli
| Project/Area Number |
23657108
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
YUI Hiroharu 東京理科大学, 理学部, 准教授 (20313017)
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| Co-Investigator(Renkei-kenkyūsha) |
OTSUKA Hidenori 東京理科大学, 理学部, 准教授 (00344193)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 光共振器 / ラマン散乱 / 顕微鏡 / 細胞 / 力学応答 / 走査型顕微鏡 / ラマン |
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| Research Abstract |
To obtain interface-selective Raman signals from a single living cell under mechanical stimuli, we have developed a scanning optical resonance cavity Raman microscope. To change the probe to one with a non-contact manner, we applied an optical pressure by laser-beam irradiation for probing the mechanical response of a single living cell at optional points utilizing a microscope. The newly developed original microscope enables us to measure the viscoelasticity of a single cell with a non-contact manner. In addition, resonant Raman signals were detected under the same microscope, which will provide information on the molecular origin of viscoelasticity in a single living cell
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Report
(3 results)
Research Products
(26 results)
