| Project/Area Number |
23657113
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 転写制御 / シグナル伝達 / 遺伝子 / 発現制御 / 細胞・組織 |
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| Research Abstract |
The neuromuscular junction (NMJ) is an essential synapse between a motor neuron and skeletal muscle. In mammals, the NMJ forms in the central region of each myotube, a multinucleated fibrous cell, and it is widely accepted that this requires the centrally localized, postsynaptic nuclei-specific expression of genes encoding NMJ proteins. The muscle-specific kinase MuSK, which governs the NMJ formation in skeletal muscle, plays an essential role in the post-synaptic transcriptional regulation. However, expression of the NMJ protein Dok-7 is not under the MuSK-dependent regulation. As an initial step toward understanding the regulatory mechanisms, we studied transcriptional regulation of the dok-7 gene.
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