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Reactions required for eukaryotic mismatch repair to function in the context of chromatin

Research Project

Project/Area Number 23657114
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Molecular biology
Research InstitutionOsaka University

Principal Investigator

TAKAHASHI Tatsuro  大阪大学, 大学院・理学研究科, 助教 (50452420)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsDNA 損傷・修復 / クロマチン / ミスマッチ修復 / 突然変異 / DNA複製 / DNA修復 / ツメガエル卵抽出液
Research Abstract

The mismatch repair system corrects replication errors to protect genomic information from mutations. The mismatch repair system functions after DNA synthesis, at the time when chromatin reassembly takes place. However, the reactions required for mismatch repair to function in the context of chromatin remain elusive. We sought factors that are involved in the mismatch repair reaction in the chromatin context, and identified several candidate factors. Our study will contribute to further understanding of the eukaryotic mismatch repair reaction.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2012 2011

All Presentation (7 results) (of which Invited: 1 results)

  • [Presentation] Inhibition of chromatin assembly by the mismatch repair system2012

    • Author(s)
      高橋 達郎
    • Organizer
      第二回 日仏がんワークショップ
    • Place of Presentation
      徳島県鳴門市
    • Related Report
      2012 Final Research Report
  • [Presentation] Coupling of DNA mismatch repair and chromatin replication2012

    • Author(s)
      高橋 達郎、滝 佳菜恵、照井 利輝、長尾 恒治、中川 拓郎、小布施 力史、升方 久夫
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Inhibition of chromatin assembly by the mismatch repair system2012

    • Author(s)
      高橋 達郎
    • Organizer
      第二回 日仏がんワークショップ
    • Place of Presentation
      徳島県鳴門市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ミスマッチ修復機構によるクロマチン形成制御2011

    • Author(s)
      高橋 達郎
    • Organizer
      構造エピゲノム研究会第4回ワークショップ 「DNA損傷とエピゲノム」(招待講演)
    • Place of Presentation
      神奈川県横浜市理研横浜研究所
    • Related Report
      2011 Research-status Report
  • [Presentation] The MutS complex inhibits nucleosome assembly around mismatch sites in Xenopus egg extracts2011

    • Author(s)
      滝 佳菜恵・高橋 達郎
    • Organizer
      Eukaryotic DNA replication & genome maintenance, Cold Spring Harbor Laboratory
    • Place of Presentation
      Cold Spring Harbor, New York, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] DNAミスマッチ修復がクロマチン複製の場で機能するための分子機構2011

    • Author(s)
      高橋 達郎
    • Organizer
      国立遺伝学研究所研究集会 「ゲノム損傷応答研究会」(招待講演)
    • Place of Presentation
      静岡県三島市国立遺伝学研究所
    • Related Report
      2011 Research-status Report
  • [Presentation] The MutS complex inhibits nucleosome assembly around mismatch sites in Xenopus egg extracts2011

    • Author(s)
      滝 佳菜恵・高橋 達郎
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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