Reactions required for eukaryotic mismatch repair to function in the context of chromatin
| Project/Area Number |
23657114
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | DNA 損傷・修復 / クロマチン / ミスマッチ修復 / 突然変異 / DNA複製 / DNA修復 / ツメガエル卵抽出液 |
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| Research Abstract |
The mismatch repair system corrects replication errors to protect genomic information from mutations. The mismatch repair system functions after DNA synthesis, at the time when chromatin reassembly takes place. However, the reactions required for mismatch repair to function in the context of chromatin remain elusive. We sought factors that are involved in the mismatch repair reaction in the chromatin context, and identified several candidate factors. Our study will contribute to further understanding of the eukaryotic mismatch repair reaction.
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Report
(3 results)
Research Products
(7 results)
