Regulatory mechanisms of brain function by alternative splicing products of fosB gene
| Project/Area Number |
23657116
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 転写 / 選択的スプライシング / 成体脳神経新生 / てんかん / うつ / 最初期遺伝子 / 側頭葉てんかん / うつ病 / 海馬硬化 / 遺伝子発現プロファイリング / AP-1転写因子 / 前初期遺伝子 |
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| Research Abstract |
Under various brain stress, expression of fosB gene which encodes subunits of AP-1 transcription factor is highly induced in the hippocampus of mouse brain. The fosB gene produces two mature mRNAs (fosB and ・fosB) by alternative splicing, and whose products differentially regulate the response to various brain stress. Our analyses of fosB-null mice and mutant mice which produce only one of the two mRNAs revealed that both of the two fosB mRNA products play distinct roles in control of the adult neurogenesis in hippocampal dentate gyrus through regulating expression of various genes, and thus suppressing epilepsy and depressive behavior.
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Report
(3 results)
Research Products
(25 results)
