Understanding the mechanism of synchronous chromosome segregation that ensures the faithful inheritance of genomic information
| Project/Area Number |
23657118
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Molecular biology
|
|---|
| Research Institution | Japanese Foundation For Cancer Research |
|---|
Principal Investigator |
SHINDO Norihisa 公益財団法人がん研究会, がん研究所実験病理部, 研究員 (00512253)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 染色体 / セパレース / 染色体分離 / コヒーシン / バイオセンサー / Cdk1キナーゼ / Cdk１キナーゼ / 紡錘体チェックポイント / 分裂期後期 |
|---|
| Research Abstract |
In order to ensure faithful chromosome segregation, cells have to coordinate the dissociation of cohesion and subsequent induction of poleward movement of disjoined sister chromatids. We found that separase inhibited the Cdk1 kinase activity upon its proteolytic activation to facilitate poleward movement of sisters. Thus, by consecutively acting as a protease and a Cdk1 inhibitor, separase coordinates two key processes to ensure faithful chromosome segregation
|
Report
(3 results)
Research Products
(18 results)
