| Project/Area Number |
23657120
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KIHARA Akio 北海道大学, 大学院・薬学研究院, 教授 (50333620)
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| Co-Investigator(Renkei-kenkyūsha) |
OBARA Keisuke 北海道大学, 大学院・薬学研究院, 助教 (30419858)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脂質 / 生体膜 / 脂質非対称 / センサー / シグナル伝達 |
|---|
| Research Abstract |
Lipid asymmetry refers to different lipid compositions between the two leaflets of the plasma membrane. We have identified the Rim101 pathway as pathway detecting a change in lipid asymmetry and transducing its signal to downstream. In the present study, we found that among factors functioning in the Rim101 pathway Rim21 is a sensor protein and that Rim9 and Dfg16 interact with Rim21 and regulate the intracellular localization and stability of Rim21. In addition, we identified Opt2 as a novel factor that keeps cellular functions when lipid asymmetry is altered.
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