| Project/Area Number |
23657122
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞間情報伝達 / 遺伝学 / 細胞・組織 / 発生・分化 / 平面内細胞極性 / PCP |
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| Research Abstract |
Most tissues and organs acquire a polarity within the plane of epithelium, which is orthogonal to the axis of apico-basal polarity, This is referred to as planar cell polarity (PCP). PCP plays essential roles in morphological development of multicellular organisms. We recently identified jitterbug (jbug) as a novel regulator of PCP by a tissue-specific RNAi screen using Drosophila as a model. Interestingly, our genetic analysis suggested that jbug is not categorized into known groups of PCP genes, indicating the existence of a novel regulatory system in the PCP pathway. In this study, we identified participants that belong to the novel PCP group and analyzed the function of a member of this group.
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