| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
In this project, we revealed the signal transductions of a small GTPase R-Ras. In cancer cells, R-Ras activity is reported to be increased by miss-regulation of guidance factors. Through biochemical research, we identified Lamellipodin as a novel effector for R-Ras. We also confirmed that the R-Ras-Lamellipodin pathway is utilized by the guidance factor signaling.
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