Molecular mechanism of cancer induction -failure in regulation of guidance signalling
Project/Area Number |
23657127
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Cell biology
|
Research Institution | Kyoto University |
Principal Investigator |
OINUMA Izumi 京都大学, 大学院・生命科学研究科, 助教 (40452297)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | R-Ras / 低分子量 G タンパク質 / ガイダンス因子 / アクチン / セマフォリン / 低分子量Gタンパク質 / 低分子量G蛋白質 / インテグリン / M-Ras |
Research Abstract |
In this project, we revealed the signal transductions of a small GTPase R-Ras. In cancer cells, R-Ras activity is reported to be increased by miss-regulation of guidance factors. Through biochemical research, we identified Lamellipodin as a novel effector for R-Ras. We also confirmed that the R-Ras-Lamellipodin pathway is utilized by the guidance factor signaling.
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Report
(3 results)
Research Products
(23 results)