Challenge to dogma in autophagy
Project/Area Number |
23657129
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Cell biology
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | オートファジー / 標的認識 / Atg / 選択的オートファジー / LC3 / ユビキチン / LC3 |
Research Abstract |
Autophagy is intracellular bulk degradation system. While recent progress in autophagy field has expanded our knowledge of the process, there are some dogma, which are widely believed but examined well. Here, we analyzed carefully one of them, a believed model for target recognition in selective autophagy. We showed that interaction between adopter proteins and LC3 is not enough to explain the recognition and there is a case that target itself is not recognized.
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Report
(3 results)
Research Products
(56 results)
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[Journal Article] Autophagosomes form at ER-mitochondria contact sites2013
Author(s)
Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A*, Yoshimori T*
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Journal Title
Nature
Volume: 495(7441)
Pages: 389-393
Related Report
Peer Reviewed
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[Journal Article] Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia2013
Author(s)
Nakashima A, Yamanaka-Tatematsu M, Fujita N, Koizumi K, Shima T, Yoshida T, Nikaido T, Okamoto A, Yoshimori T, Saito S
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Journal Title
Autophagy
Volume: 9(3)
Pages: 303-316
Related Report
Peer Reviewed
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[Journal Article] Critical roles for lipomannan and lipoarabinomannan in cell wall integrity of mycobacteria and pathogenesis of tuberculosis2013
Author(s)
Fukuda T, Matsumura T, Ato M, Hamasaki M, Nishiuchi Y, Murakami Y, Maeda Y, Yoshimori T, Matsumoto S, Kobayashi K, Kinoshita T, Morita YS
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Autophagosomes form at ER.mitochondria contact sites2013
Author(s)
Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T
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Journal Title
Nature
Volume: 495
Issue: 7441
Pages: 389-93
DOI
Related Report
Peer Reviewed
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[Journal Article] Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma2012
Author(s)
Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N
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Journal Title
Int J Cancer
Volume: 131(3)
Pages: 548-557
Related Report
Peer Reviewed
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[Journal Article] Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection2012
Author(s)
Matsumoto Y, Hayashi Y, Omori H, Honda T, Daito T, Horie M, Ikuta K, Fujino K, Nakamura S, Schneider U, Chase G, Yoshimori T, Schwemmle M, Tomonaga K
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Journal Title
Cell Host Microbe
Volume: 11(5)
Pages: 492-503
NAID
Related Report
Peer Reviewed
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[Journal Article] Jo EK.Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action2012
Author(s)
Kim JJ, Lee HM, Shin DM, Kim W, Yuk JM, Jin HS, Lee SH, Cha GH, Kim JM, Lee ZW, Shin SJ, Yoo H, Park YK, Park JB, Chung J, Yoshimori T
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Journal Title
Cell Host Microbe
Volume: 11(5)
Pages: 457-468
Related Report
Peer Reviewed
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[Journal Article] Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans2012
Author(s)
Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Gupta V, Blanke SR, Delgado A, Romero-Gallo J, Ramjeet MS, Mascarenhas H, Peek RM, Correa P, Streutker C, Hold G, Kunstmann E, Yoshimori T, Silverberg MS, Girardin SE, Philpott DJ, El Omar
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Journal Title
Gastroenterology
Volume: 142(5)
Pages: 1160-1171
Related Report
Peer Reviewed
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[Journal Article] Autophagy guards against Cisplatin-induced acute kidney injury2012
Author(s)
Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H*, Matsui I, Niimura F, Matsusaka T, Fujita N, Yoshimori T, Isaka Y*, Rakugi H
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Journal Title
Am J Pathol
Volume: 180(2)
Pages: 517-525
Related Report
Peer Reviewed
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[Journal Article] Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans2012
Author(s)
Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Gupta V, Blanke SR, Delgado A, Romero-Gallo J, Ramjeet MS, Mascarenhas H, Peek RM, Correa P, Streutker C, Hold G, Kunstmann E, Yoshimori T, Silverberg MS, Girardin SE, Philpott DJ, El Omar E, Jones NL
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Journal Title
Gastroenterology.
Volume: 142
Issue: 5
Pages: 1160-71
DOI
Related Report
Peer Reviewed
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[Journal Article] Autophagy guards against Cisplatin-induced acute kidney injury.2012
Author(s)
Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H*, Matsui I, Niimura F, Matsusaka T, Fujita N, Yoshimori T, Isaka Y*, Rakugi H.
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Journal Title
Am J Pathol.
Volume: 180
Pages: 517-25
Related Report
Peer Reviewed
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[Journal Article] Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma2011
Author(s)
Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N
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Journal Title
Int.J.Cancer
Volume: 131
Issue: 3
Pages: 548-57
DOI
Related Report
Peer Reviewed
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