Study of Golgi pH sensor and the mechanism for the localization
| Project/Area Number |
23657131
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
MAEDA Yusuke 大阪大学, 微生物病研究所, 准教授 (00294124)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ゴルジ装置 / pHホメオスタシス / pHセンサー / ｐH ホメオスタシス / pH |
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| Research Abstract |
（1）As an important clue to identify a Golgi pH sensor or its downstream factor, protein A whose overexpression corrects the mutant phenotypes such as delayed transport and impaired glycosylation, and protein B whose overexpression cancels the normalizing effect of protein A, were identified by expression cloning.
（2）Impaired complex formation of glycosyltranferases but not their mis-localization in the Golgi seemed one of the mechanisms for impaired glycosylation.
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Report
(3 results)
Research Products
(10 results)
