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Clarification of the molecular mechanisms that degitize Wnt signaling.

Research Project

Project/Area Number 23657132
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cell biology
Research InstitutionKyushu University

Principal Investigator

ISHITANI Tohru  九州大学, 生体防御医学研究所, 准教授 (40448428)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsWntシグナル / 二機能性制御因子
Research Abstract

During axis-formation in vertebrate tissues, cells sense the concentration of Wnt ligands and convert its information into the digital information that directs the regulation of selective gene expression. In this study, we investigated this Wnt signaling-degitizing system and found that DP1 protein is involved in this system. We also generated the new experimental systems for observing Wnt signaling activity in living animals.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results) Remarks (3 results)

  • [Journal Article] Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/β-catenin signaling-reporter transgenic zebrafish2012

    • Author(s)
      Shimizu N, Kawakami K, *Ishitani T
    • Journal Title

      Developmental Biology

      Volume: 370. Issue: 1 Pages: 71-85

    • DOI

      10.1016/j.cellsig.2012.09.017

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.2012

    • Author(s)
      Kim WT, Kim H, Katanaev VL, Joon Lee S, Ishitani T, Cha B, Han JK, Jho EH.
    • Journal Title

      EMBO Journal

      Volume: 31 Issue: 16 Pages: 3384-3397

    • DOI

      10.1038/emboj.2012.181

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/β-catenin signaling-reporter transgenic zebrafish.2012

    • Author(s)
      Shimizu N, Kawakami K, Ishitani T.
    • Journal Title

      Developmental Biology

      Volume: 370 Issue: 1 Pages: 71-85

    • DOI

      10.1016/j.ydbio.2012.07.016

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Exploration of Tcf/Lef function using a highly responsive Wnt/β-catenin signaling-reporter transgenic zebrafish2012

    • Author(s)
      Nobuyuki Shimizu, Koichi Kawakami, Tohru Ishitani
    • Organizer
      第18回小型魚類研究会
    • Place of Presentation
      京都大学
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] A dual and opposite role of NLK-mediated Lef1 phosphorylation on the Wnt/beta-catenin signaling2012

    • Author(s)
      Tohru Ishitani, Shizuka Ishitani
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同年会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2012-05-31
    • Related Report
      2012 Final Research Report
  • [Presentation] A dual and opposite role of NLK-mediated Lef1 phosphorylation on the Wnt/β-catenin signaling2012

    • Author(s)
      Tohru Ishitani, Shizuka Ishitani
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会 合同年 会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Live imaging of Tcf/Lef activity in developing, growing, and regenerating tissues of the highly responsive Wnt/β-catenin signaling reporter-transgenic zebrafish2012

    • Author(s)
      Nobuyuki Shimizu, Tohru Ishitani
    • Organizer
      the 10th International Conference on Zebrafish Development and Genetics
    • Place of Presentation
      Madison, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Exploration of Tcf/Lef function using a highly responsive Wnt/β-catenin signaling-reporter transgenic zebrafish2012

    • Author(s)
      Nobuyuki Shimizu, Koichi Kawakami, and Tohru Ishitani
    • Organizer
      第18回小型魚類研究会
    • Place of Presentation
      京都大学芝蘭会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis of the spatiotemporal dynamics and its regulatory mechanisms of Wnt/β-catenin and Hedgehog signaling pathways using the transgenic zebrafish lines carrying the signaling reporters2011

    • Author(s)
      Nobuyuki Shimizu, Tohru Ishitani
    • Organizer
      第17回小型魚類研究会
    • Place of Presentation
      東レ総合研修センター
    • Year and Date
      2011-09-08
    • Related Report
      2012 Final Research Report
  • [Presentation] シグナル可視化ゼブラフィッシュを用いたWntシグナルの時空間的動態とその制御機構の解析2011

    • Author(s)
      Nobuyuki Shimizu, Tohru Ishitani
    • Organizer
      第17回小型魚類研究会
    • Place of Presentation
      三島市東レ研修センタ-
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/crs/top.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 石谷研究室プログレス

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/crs/sub11.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/crs/top.html

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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