| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
Cell division needs hundreds of protein phosphorylation that should be temporally and spacially regulated. This research project focused on functions of protein phosphatases, that attaracted less attention than protein kinases till today. We found that multiple phosphatase complexes paly differertn roles for faithful chromosome segregation on cell division at kinetochores. We also found that alpha-endosulfine, an imprtant regulator for other kind of phosphatase, is phopshorylated on its tyrosine residue. Importance of the residue was shown in a test tube by us. These results imply how protein phosphatases could contribute to the cell division in combination with protein kinases.
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