| Project/Area Number |
23657136
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | University of Hyogo |
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Principal Investigator |
YOSHIDA Hiderou 兵庫県立大学, 大学院・生命理学研究科, 教授 (60378528)
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| Co-Investigator(Renkei-kenkyūsha) |
WAKABAYASHI Sadao 兵庫県立大学, 大学院・生命理学研究科, 准教授 (80148436)
TANIGUCHI Mai 兵庫県立大学, 大学院・生命理学研究科, 助教 (00423898)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞構造・機能 / ストレス応答 / 細胞生物学 / オルガネラ / ゴルジ体 / 小胞体 / 転写制御 / 糖鎖 / 神経 / 細胞小器官 / 小胞輸送 / 膜脂質 |
|---|
| Research Abstract |
The Golgi stress response is an autoregulatory mechanism controlling the capacity of the Golgi apparatus in accordance with cellular demands. We analyzed what kinds of molecular changes activate the Golgi stress response, and revealed that deficiency of glycosylation in the Golgi apparatus is responsible for activation of the Golgi stress response.
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