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Induced reprogrammiong of cell fate in C. elegans

Research Project

Project/Area Number 23657144
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Developmental biology
Research InstitutionNagoya University

Principal Investigator

TAKAGI Shin  名古屋大学, 理学(系)研究科(研究院), 准教授 (90171420)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords分化運命 / C. elegans / 分化運命決定 / 転写因子 / 線虫C. elegans
Research Abstract

Recent studies show that ectopic expression of specific combinations of transcription factors can change identity of apparently differentiated cells. To reveal the underlying mechanisms of reprogramming we here take the worm C. elegans, in which the developmental fate of each cell appears to be determined strictly. In larval worms that have completed neurogenesis, forced expression of a mixture of transcription factors induced production of cells that ectopically express pan-neuronal markers. Many of them assumed neuron-like morphology and expressed a marker for differentiated sensory cells, suggesting they underwent complete reprogramming, while some assumed non-neuron-like morphology and co-expressed a maker of a non-neuronal cell type. Thus, we have successfully established an in vivo model for deciphering the cellular contexts necessary for cell reprogramming.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2013 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] A shift of the TOR adaptor from rictor toward raptor by semaphorin in C. elegans2011

    • Author(s)
      Nukazuka, A., Tamaki, S., Matsumoto, K., Oda, Y., Fujisawa, H., and Takagi, S
    • Journal Title

      Nature Commun

      Volume: 2 Issue: 1 Pages: 484-484

    • DOI

      10.1038/ncomms1495

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Combinatorial expression of defined transcription factors induces ectopic neurons in C. elgans larvae2013

    • Author(s)
      Masaki Shimojou, Shin Takagi
    • Organizer
      日本発生生物学会第46回年会
    • Place of Presentation
      くにびきメッセ(松江)
    • Year and Date
      2013-05-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Combinatorial expression of defined transcription factors2013

    • Author(s)
      下條 真生.
    • Organizer
      日本発生生物学会第46回年会
    • Place of Presentation
      くにびきメッセ 松江市
    • Related Report
      2013 Annual Research Report
  • [Presentation] セマフォリンによる翻訳制御を介したC. elegans表皮形態形成の調節2011

    • Author(s)
      高木 新
    • Organizer
      第84回日本生化学会大会(招待講演)
    • Place of Presentation
      京都国際会議場
    • Related Report
      2011 Research-status Report
  • [Presentation] Combinatorial expression of defined transcription factors induces ectopic neurons in C. elegans larvae

    • Author(s)
      下條 真生
    • Organizer
      日本発生生物学会年会
    • Place of Presentation
      くにびきメッセ (松江)
    • Related Report
      2012 Research-status Report
  • [Remarks] 名古屋大学大学院理学研究科生命理学専攻 M7 研究室

    • URL

      http://www.bio.nagoya-u.ac.jp/~m7home/

    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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