An ancient origin of neurogenetic mechanisms for neocortical layer-specific neurons
| Project/Area Number |
23657151
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
HIRATA Tatsumi 国立遺伝学研究所, 総合遺伝研究系, 准教授 (80260587)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI K Ikuo 国立遺伝学研究所, 総合遺伝研究系, 研究員 (30600548)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経 / 進化 / 発生 / 大脳新皮質 / 終脳新皮質 |
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| Research Abstract |
The most remarkable characteristic of the mammalian neocortex is its layered structure. Because all, but only the mammalian species, have this layered structure in the telencephalon, it has been accepted as a “new” brain structure that recently evolved in the mammalian lineage. We, however, found that the non-mammalian chicken has neurons homologous to mammalian neocortical layer-specific neuron subtypes and can activate the mammalian-type neurogenetic mechanism to produce them. The results suggest that the so-called “mammalian-type” neocortical neurogenetic mechanism was already inherent in the last common ancestor of mammals and birds before actual evolution of the layered neocortex in the mammalian lineage.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Guidepost neurons for the lateral olfactory tract : expression of metabotropic glutamate receptor 1 and linnervation by glutamatergic olfactory bulb axons2012
Author(s)
Hirata, T., Kumada, T., Kawasaki, T., Furukawa, T., Aiba, A., Conquet, F., Saga, Y. and Fukuda, A.
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Journal Title
Dev. Neurobiol
Volume: (in press)
Issue: 12
Pages: 1559-1576
DOI
Related Report
Peer Reviewed
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[Journal Article] Cartilage acidic protein-1B(LOTUS), an endogenous Nogo receptor antagonist for axon tract formation2011
Author(s)
Sato, Y., Iketani, M., Kurihara, Y., Yamaguchi, M., Yamashita, N., Nakamura, F., Arie, Y., Kawasaki, T., Hirata, T., Abe, T., Kiyonari, H., Strittmatter, S. M., Goshima, Y. and Takei, K.
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Journal Title
Science
Volume: Vol.333
Issue: 6043
Pages: 769-773
DOI
Related Report
Peer Reviewed
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