An ancient origin of neurogenetic mechanisms for neocortical layer-specific neurons

• Project/Area Number: 23657151
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Developmental biology
• Research Institution: National Institute of Genetics
• Principal Investigator: HIRATA Tatsumi 国立遺伝学研究所, 総合遺伝研究系, 准教授 (80260587)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI K Ikuo 国立遺伝学研究所, 総合遺伝研究系, 研究員 (30600548)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 神経 / 進化 / 発生 / 大脳新皮質 / 終脳新皮質

Research Abstract

The most remarkable characteristic of the mammalian neocortex is its layered structure. Because all, but only the mammalian species, have this layered structure in the telencephalon, it has been accepted as a “new” brain structure that recently evolved in the mammalian lineage. We, however, found that the non-mammalian chicken has neurons homologous to mammalian neocortical layer-specific neuron subtypes and can activate the mammalian-type neurogenetic mechanism to produce them. The results suggest that the so-called “mammalian-type” neocortical neurogenetic mechanism was already inherent in the last common ancestor of mammals and birds before actual evolution of the layered neocortex in the mammalian lineage.

Research Products

• [Journal Article] Neocortical neurogenesis is not really “neo”: a new evolutionary model derived from a comparative study of chick pallial development. (2013)
  • Author(s): I.K. Suzuki
  • Journal Title: Dev. Growth Differ. (review) Volume: 55 Issue: 1 Pages: 173-187
  • DOI: 10.1111/dgd.12020
  • Peer Reviewed
• [Journal Article] Evolutionary conservation of neocortical neurogenetic program in the mammals and birds (2012)
  • Author(s): I.K. Suzuki
  • Journal Title: BioArchitecture (review) Volume: 2 Issue: 4 Pages: 1-6
  • DOI: 10.4161/bioa.21032
  • Peer Reviewed
• [Journal Article] The Temporal Sequence of the Mammalian Neocortical Neurogenetic Program Drives Mediolateral Pattern in the Chick Pallium (2012)
  • Author(s): Suzuki, I.
  • Journal Title: Developmental Cell Volume: 22 Issue: 4 Pages: 1-8
  • DOI: 10.1016/j.devcel.2012.01.004
  • Peer Reviewed
• [Journal Article] Guidepost neurons for the lateral olfactory tract : expression of metabotropic glutamate receptor 1 and linnervation by glutamatergic olfactory bulb axons (2012)
  • Author(s): Hirata, T., Kumada, T., Kawasaki, T., Furukawa, T., Aiba, A., Conquet, F., Saga, Y. and Fukuda, A.
  • Journal Title: Dev. Neurobiol Volume: (in press) Issue: 12 Pages: 1559-1576
  • DOI: 10.1002/dneu.22030
  • Peer Reviewed
• [Journal Article] Updated interpretation of the principles of neural development (2012)
  • Author(s): T. Hirata
  • Journal Title: Development (book review) Volume: 139 Issue: 24 Pages: 5-6
  • DOI: 10.1242/dev.084632
  • Peer Reviewed
• [Journal Article] Induction of axon growth arrest without growth cone collapse through the N-terminal region of four-transmembrane glycoprotein M6a (2011)
  • Author(s): Y.Sato
  • Journal Title: Dev.Neurobiol. Volume: 71 Issue: 9 Pages: 733-746
  • DOI: 10.1002/dneu.20941
  • Peer Reviewed
• [Journal Article] Cartilage acidic protein-1B(LOTUS), an endogenous Nogo receptor antagonist for axon tract formation (2011)
  • Author(s): Sato, Y., Iketani, M., Kurihara, Y., Yamaguchi, M., Yamashita, N., Nakamura, F., Arie, Y., Kawasaki, T., Hirata, T., Abe, T., Kiyonari, H., Strittmatter, S. M., Goshima, Y. and Takei, K.
  • Journal Title: Science Volume: Vol.333 Issue: 6043 Pages: 769-773
  • DOI: 10.1126/science.1204144
  • Peer Reviewed
• [Journal Article] Actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a (2011)
  • Author(s): Y.Sato
  • Journal Title: PLoS One Volume: e26702 Issue: 12 Pages: 1-13
  • DOI: 10.1371/journal.pone.0026702
  • Peer Reviewed
• [Presentation] The making of the mammalian neocortex (2013)
  • Author(s): T. Hirata
  • Organizer: CDB Symposium . The Making of a Vertebrate
  • Place of Presentation: 神戸
• [Presentation] The making of the mammalian neocortex (2013)
  • Author(s): T. Hirata
  • Organizer: CDB Symposium – The Making of a Vertebrate
  • Place of Presentation: Kobe, Japan
  • Invited
• [Presentation] Mammalian-type neurogenetic potential in chick pallial neural progenitors (2012)
  • Author(s): T. Hirata
  • Organizer: Symposium "Circuit Construction in the Mammalian Cerebral Cortex: Genetic and Imaging Approaches"
  • Place of Presentation: 三島
• [Presentation] Neocortical neurogenesis is not really "neo": a new evolutionary model derived from a comparative study of the chick pallial development (2012)
  • Author(s): I. K. Suzuki and T. Hirata
  • Organizer: 7th International Chick Meeting
  • Place of Presentation: 名古屋
• [Presentation] Neocortical neurogenesis is not really “neo”: a new evolutionary model derived from a comparative study of the chick pallial development (2012)
  • Author(s): I.K. Suzuki
  • Organizer: 7th International Chick Meeting
  • Place of Presentation: Nagoya, Japan
  • Invited
• [Presentation] Mammalian-type neurogenetic potential in chick pallial neural progenitors (2012)
  • Author(s): T. Hirata
  • Organizer: Symposium “Circuit Construction in the Mammalian Cerebral Cortex: Genetic and Imaging Approaches
  • Place of Presentation: Mishima, Japan
  • Invited
• [Presentation] Axon outgrowth regulated by four-transmembrane protein M6a (2012)
  • Author(s): T. Hirata
  • Organizer: US/Japan Brain Research Cooperative Program. Growth cones and axon regeneration entering the age of informatics
  • Place of Presentation: New Orleans, USA
  • Invited
• [Presentation] Generation program of neocortical layer-specific neurons predates mammalian emergence (2011)
  • Author(s): I. K. Suzuki, T. Gojobori and T. Hirata
  • Organizer: Society for Molecular Biology and Evolution (SMBE)
  • Place of Presentation: 京都
  • Year and Date: 2011-07-28
• [Presentation] Generation program of neocortical layer-specific neurons predates mammalian emergence (2011)
  • Author(s): I. K. Suzuki
  • Organizer: Society for Molecular Biology and Evolution (SMBE)(招待講演)
  • Place of Presentation: 京都
• [Presentation] Distinct functions of PlnA family in the central olfactory projection (2011)
  • Author(s): T. Kawasaki
  • Organizer: 第44回日本発生生物学会年会
  • Place of Presentation: 沖縄
• [Presentation] M6 proteins regulate axon outgrowth in mouse callosal neurons (2011)
  • Author(s): S. Mita
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Book] 大脳新皮質における神経新生プログラムの哺乳類と鳥類との進化的な保存性 (2012)
  • Author(s): 鈴木郁夫、平田たつみ
  • URL: http://first.lifesciencedb.jp/archives/4739
• [Remarks] ホームページ等 研究機関のニュース
  • URL: http://www.nig.ac.jp/Research-Highlights/992/1029.html
• [Remarks]
  • URL: http://www.nig.ac.jp/english/highlight/991/1030.html
• [Remarks] Developmental Cell のビデオ抄録
  • URL: http://download.cell.com/developmental-cell/mmcs/journals/1534-5807/PIIS153458071200038X.mmc2.mp4
• [Remarks] Faculty of 1000
  • URL: http://f1000.com/prime/14257009
• [Remarks] インターネットニュースにも多数取り上げられた。
• [Remarks]
  • URL: http://www.nig.ac.jp/Research-Highlights/992/1029.html