| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
The polished ricegene in Drosophilaencodes extremely small 11 or 32-aa long peptides (PRI peptides) that do not include any signal sequences, although genetic analysis have shown that prishows non-cell autonomous effects to neighboring cells. To elucidate molecular mechanisms underlying the non-cell autonomous signaling by the prigene, we tried to identify PRI peptides-associating proteins using cultured cells. Although we failed to raise specific antibody against PRI peptides, fusion peptides with molecular tags were effectively precipitated with anti-tag antibodies. We identified several proteins that are co-precipitated with PRI fusion peptides.
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