How do non-signalsequence small peptides transmit intercellular signals?
| Project/Area Number |
23657152
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
KAGEYAMA Yuji 神戸大学, 遺伝子実験センター, 准教授 (90335480)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | ショウジョウバエ / 短鎖ペプチ / 細胞間シグナル伝達 / 発生遺伝 / 短鎖ペプチド / シグナル伝達 / マイクロペプチド / 細胞間情報伝達 / 細胞突起形成 |
|---|
| Research Abstract |
The polished ricegene in Drosophilaencodes extremely small 11 or 32-aa long peptides (PRI peptides) that do not include any signal sequences, although genetic analysis have shown that prishows non-cell autonomous effects to neighboring cells. To elucidate molecular mechanisms underlying the non-cell autonomous signaling by the prigene, we tried to identify PRI peptides-associating proteins using cultured cells. Although we failed to raise specific antibody against PRI peptides, fusion peptides with molecular tags were effectively precipitated with anti-tag antibodies. We identified several proteins that are co-precipitated with PRI fusion peptides.
|
Report
(3 results)
Research Products
(8 results)
